Cell adhesion and motility require a dynamic remodelling of the membrane-associated actin cytoskeleton in response to extracellular stimuli that are primarily transmitted through receptor tyrosine kinases. In a cellular model system for tyrosine phosphorylation-based growth factor signaling, we observed that annexin A2 is tyrosine-phosphorylated upon insulin receptor activation. The phosphoryla...

China is currently accelerating construction of its strategic petroleum reserves. How should China fill the SPR in a cost-effective manner in the short-run? Howmight this affect world oil prices? Using a dynamic programming model to answer these questions, the objective of this paper is to minimize the stockpiling costs, including consumer surplus as well as crude acquisition and holding costs....

differences between stress-based and strain-based criteria are investigated in seismic performance evaluation of the arch dams in time domain. a numerical model of the coupled dam-reservoir-foundation system is prepared with the finite element technique. reservoir is modeled using the eulerian approach as a compressible domain, and the foundation rock is assumed to be massless. dynamic equilibr...

The internal fabric of a deformed rock represents the state of finite strain. In some special cases the fabrics also record the strain history of the deformed body. These special cases can profitably be utilized to compare the predictions of dynamic models and strain paths in natural deformations. In this contribution, the concept of deformation path in the study of ductile shear zones has been...

We recently identified a novel human protein kinase, p160 ROCK, as a putative downstream target of the small GTPase Rho. Using the human ROCK cDNA as a probe, we isolated cDNA of two distinct, highly related sequences from mouse libraries. One encoded a mouse counterpart of human ROCK (ROCK-I), and the other encoded a novel ROCK-related kinase (ROCK-II). Like ROCK/ROCK-I, ROCK-II also bound to ...

This paper is an overview of quasistatic measurement technique used to determine mechanical properties of sound absorbing materials. Experimental context and behaviour of polymer foam and rock wool are summarized. Concerning parameters are: static and dynamic strains, dynamic effects such as skeleton resonance and coupling with saturating fluid. Material anisotropy and frequency dependance of c...