T his symposium is devoted to evidence based medicine (EBM) and the ethical issues it raises. Since Sir Archie Cochrane’s seminal Nuffield Provincial Hospitals Trust lectures in 1972 and their publication as the Rock Carling monograph for that year, Effectiveness and Efficiency: Random Reflections on Health Services, the idea that medical interventions and health services should be evaluated an...

Seven years seems the right term for an editorship. It is a time for the land that has been sown and reaped to remain uncultivated for a while (see Exodus or Leviticus, The Bible)—time for a sabbatical. When I came on in 2010, Evidence-Based Medicine (EBM) was already well established (for 15 years, its adolescence) as was the field of EBM (>3 years earlier, its birth). At the beginning, the jo...

The Electron Beam Melting (EBM) manufacturing process is emerging as an additional method for producing orthopaedic devices in several materials, including Co-Cr-Mo Alloy. This work presents the chemical, microstructural and mechanical properties of several test specimens produced by the EBM process before and after a post‐EBM Heat treatment. Comparisons are made to the properties of Co-Cr-Mo m...

BACKGROUND Alzheimer's disease and related disorders (ADRD) are prevalent in older adults, increase the costs of chronic heart failure (CHF) management, and may be associated with undertreatment of cardiovascular disease. OBJECTIVE The purpose of our study was to determine the relationship between comorbid ADRD and CHF medication use and adherence among Medicare beneficiaries with CHF. METH...

PURPOSE To investigate the production of the epithelial basement membrane (EBM) component mRNAs at time points before lamina lucida and lamina densa regeneration in anterior stromal cells after corneal injury that would heal with and without fibrosis. METHODS Rabbit corneas were removed from 2 to 19 days after -4.5D or -9.0D photorefractive keratectomy (PRK) with the VISX S4 IR laser. Corneas...