We elucidate the relationship between threshold and expectation-threshold of a down-set. Qualitatively, our main result demonstrates that there exist down-sets with polynomial gaps their thresholds expectation-thresholds; in particular, logarithmic gap predictions Kahn–Kalai Talagrand (recently proved by Park–Pham Frankston–Kahn–Narayanan–Park) about up-sets do not apply to down-sets. Quantitat...

BACKGROUND This paper is a response to the suggestion by Sacristán et al that clinicians can increase their clinical freedom by undertaking individualised economic analyses that demonstrate that interventions, which at a population level do not reach conventional thresholds of cost-effectiveness, do so in particular patients. DISCUSSION In this reply, I question the presumption that "clinical...

The aim of this paper is to promote the efficiency in the process of incorporating new health technologies, as well as to guide their implementation by physicians. An iterative method has been used to draw a checklist based on parsimony and measurability criteria. Authors made a first version of the checklist on the basis of theoretical literature and economic evaluation guidelines. This prelim...