The symmetric core of the nuclear pore complex can be considered schematically as a series of concentric cylinders. A peripheral cylinder coating the pore membrane contains the previously characterized, elongated heptamer that harbors Sec13-Nup145C in its middle section. Strikingly, Sec13-Nup145C crystallizes as a hetero-octamer in two space groups. Oligomerization of Sec13-Nup145C was confirme...

An understanding of how the nuclear pore complex (NPC) mediates nucleocytoplasmic exchange requires a comprehensive inventory of the molecular components of the NPC and a knowledge of how each component contributes to the overall structure of this large molecular translocation machine. Therefore, we have taken a comprehensive approach to classify all components of the yeast NPC (nucleoporins). ...

One of the most dramatic causes of damage of structures during earthquakes has been the development of liquefaction in saturated cohesionless deposits. These deposits have tendency to densify when subjected to earthquake loading. However, when saturated, the tendency to densify causes the excess pore water pressure to increase. This, in turn, results in the effective stress of soil to decrease....

The mechanism of reversible electric breakdown of lipid membranes is studied. The following stages of the process of pore development are substantiated. Hydrophobic pores are formed in the lipid bilayer by spontaneous fluctuations. If these water-filled defects extend to a radius of 0.3 to 0.5 nm, a hydrophilic pore is formed by reorientation of the lipid molecules. This process is favoured by ...

Immiscible two-phase flow of Newtonian fluids in porous media exhibits a power law relationship between rate and pressure drop when the is such that viscous forces compete with capillary forces. When large enough for to dominate, there crossover linear relation drop. Different values exponent relating regime where two have been reported different experimental numerical studies. We investigate i...

We propose a mechanism for the stabilization and destabilization of cell membranes by multivalent ions with an emphasis on its implications for the division and fusion of cells. We find that multivalent cations preferentially adsorbed onto a membrane dramatically change the membrane stability. They not only reduce the surface charge density of the membrane but also induce a barrier to pore grow...

mil-53-cu has been synthesized hydrothermally and has been used for the first time for gas separation. mil-53-cu shows adsorption capacities of 8.1, 0.7 and 0.5 m.mol/g, respectively, for ch4, co2 and h2 at 30 bar and 298 k. the high ch4 adsorption capacity of mil-53-cu maybe attributed to the high pore volume and large number of open metal sites. the high selectivity for ch4 over co2 (11.5) an...