26 Release of cytochrome c from mitochondria to the cytosol is a critical step for 27 downstream caspase-mediated apoptotic signal transduction in ischemia/reperfusion 28 (I/R)-induced myocardial tissue injury. 10-N-nonyl acridine orange (NAO), a 29 cardiolipin-specific dye, has been shown to inhibit Bid-mediated cytochrome c release 30 from isolated mitochondria in vitro; however, the possible...

BACKGROUND Long-acting muscarinic antagonists (LAMAs) are recommended for the treatment of chronic obstructive pulmonary disease (COPD). Glycopyrrolate/eFlow® is an investigational drug-device combination of the LAMA glycopyrrolate administered by an eFlow® Closed System (eFlow® CS) nebulizer. The GOLDEN 2 (NCT01706536) and GOLDEN 6 (NCT02038829) Phase II, multicenter studies were conducted to ...

Bax is a proapoptotic member of the Bcl-2 family of proteins. The Bax protein is dormant in the cytosol of normal cells and is activated upon induction of apoptosis. In apoptotic cells, Bax gets translocated to mitochondria, inserts into the outer membrane, oligomerizes and triggers the release of cytochrome c, possibly by channel formation. The BH3 domain-only protein Bid induces a conformatio...

?lahi dinler aras?nda daha somut, dünyevi ve ak?lc? argümanlar? öne ç?karan monoteist Yahudilik, kutsal kitap külliyat? olmak üzere dinin temel unsurlar?n? etnik ak?l ile uzla?? içinde izah ederken bu yorumlayan Talmud/Rabbani gelene?i rasyonel delilleri kendi dönemlerinin felsefi zihin dünyas?na uygun olarak ikna iman?n dogmatik yap?s?n? güçlendirmek için kullanm??t?. Daha sonraki dönemlerde y...

In mitochondrion-dependent type II apoptosis, BH3-interacting domain death agonist (BID) and BCL-2-associated X protein (BAX) promote death ligand and receptor-mediated cell death. In porcine ovaries, the levels of BID and BAX increase in follicular granulosa cells during atresia. In the present study, to confirm the pro-apoptotic activity of BID and BAX in granulosa cells, we examined the effe...

Although secret sharing techniques have been applied to implement secure electronic sealed-bid auction for a long time, problems and attacks still exist in secret-sharing-based electronic sealed-bid auction schemes. In this paper, a new secret-sharing-based first-bid e-auction scheme is designed to achieve satisfactory properties and efficiency. Correctness and fairness of the new auction are b...

Efficient general secure multiparty computation (MPC) protocols were previously proposed, and the combination with the efficient auction circuits achieves the efficient sealed-bid auctions with the full privacy and correctness. However, the combination requires that each bidder submits ciphertexts of bits representing his bid, and their zeroknowledge proofs. This cost amounts to about 80 multi-...

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the loss of motoneurons in the spinal cord, brainstem and motor cortex. Mutations in the superoxide dismutase 1 (SOD1) gene represent a frequent genetic determinant and recapitulate a disease phenotype similar to ALS when expressed in mice. Previous studies using SOD1(G93A) transgenic mice have suggested a...

Let I be the set of distinct items to be sold in a combinatorial auction, and let N = | I |. The terms auction set and auction size refer to I and N, respectively. Bidders can place bids on any item set, which refers to any non-empty subset of I. A bid b can be represented by the tuple b = (S, v, id). Here S denotes the item set the bid was placed on (∅ ⊂ S ⊆ I), also called the span of the bid...