A new reference clinical atlas of facial signs dedicated to photoaging was applied to 301 Chinese women of various ages through standardized photographs. Such approach aimed at better describing the facial changes induced by both real/chronological age and sun exposure and their respective impact on two subcohorts of different behavior with regard to sun exposure. A total of 28 various facial s...

Diverticular disease of the sigmoid colon is an increasingly common clinical problem in the ageing population of western industrialised countries but the mechanism by which the disease develops remains unknown. The muscular abnormality is the most striking and consistent feature and this has been studied by light and electron microscopy in 25 surgical specimens of uncomplicated diverticular dis...

BACKGROUND Multiple therapies involving ablative and nonablative techniques have been developed for rejuvenation of photodamaged skin. Monopolar radiofrequency (RF) is emerging as a gentler, nonablative skin-tightening device that delivers uniform heat to the dermis at a controlled depth. OBJECTIVE We evaluated the clinical effects and objectively quantified the histologic changes of the nona...

background and objective: rosacea is a common and ill-defined disease and demodex folliculorum has been reported in rosacea in a number of clinical studies. since demodex mite is present in many healthy individuals, the mite may have a pathogenic role only when it is present in high densities. therefore, in this study, the possible role of demodex folliculorum and the importance of mite density...

OBJECTIVES AGING SIGNS CAN BE CLASSIFIED INTO FOUR MAIN CATEGORIES: wrinkles/texture, lack of firmness of cutaneous tissues (ptosis), vascular disorders, and pigmentation heterogeneities. During a lifetime, skin will change in appearance and structure not only because of chronological and intrinsic processes but also due to several external factors such as gravity, sun and ultraviolet exposure,...

Rosacea is a common skin condition that affects an estimated 13 million Americans, with almost half of these patients between the ages of 30 and 50 years old [1]. It is a relapsing, chronic dermatosis that develops in stages and is characterized by a defect in vascular responsiveness [2,3]. Most often, fair-skinned individuals are seen first with flushing and blushing episodes followed by persi...

Surgical biopsies of the heart and early needle "biopsies" at necropsy now permit ultrastructural investigations into many cardiac conditions. There are, however, very few such studies on normal human myocardium and none are available on human or animal endocardium. The commonest surgical specimens from the heart are from the left or right atrial appendages, and this material has been used to s...

Chronic exposure to environmental ultraviolet radiation (UVR) plays a key role both in photocarcinogenesis and induction of accelerated skin ageing. Sailors commonly experience a significant number of cutaneous problems, related to the exposure to environmental factors due to their working conditions. Among these factors, sun exposure is able to determine both acute and chronic skin damage, mos...

Skin aging is primarily due to alterations in the dermal extracellular matrix, especially a decrease in collagen I content, fragmentation of collagen fibrils, and accumulation of amorphous elastin material, also known as elastosis. Growth factors and cytokines are included in several cosmetic products intended for skin rejuvenation because of their ability to promote collagen synthesis. Matriki...

Because rosacea is uncommon in the pediatric population, care must be taken to exclude other papulopustular disorders. Children can present with vascular, papulopustular, and/or ocular findings. Importantly, ocular symptoms can appear before the cutaneous symptoms of rosacea, leading to misdiagnosis. Rosacea is a clinical diagnosis, but histopathologic examination typically reveals dilated vess...