Sleep complaints increase profoundly with age; prevalence estimates of insomnia in the elderly reach up to 37%. The three major types of nocturnal complaints are difficulties initiating (DIS) and maintaining (DMS) sleep and early morning awakening (EMA), of which the latter appears most characteristic for aging. The neural correlates associated with these complaints have hardly been investigate...

Virtues, broadly understood as stable and robust dispositions for certain responses across morally relevant situations, have been a growing topic of interest in psychology. A central topic of discussion has been whether studies showing that situations can strongly influence our responses provide evidence against the existence of virtues (as a kind of stable and robust disposition). In this revi...

BACKGROUND The US Food and Drug Administration (FDA) and European Medicines Agency (EMA) have approved updated dose recommendations for intravenous colistin in patients with various degrees of renal function. We assessed the recommendations in relation to their ability to achieve clinically relevant plasma colistin concentrations. METHODS Pharmacokinetic data from 162 adult critically ill pat...

As part of ongoing research towards integrating an articulatory synthesizer into a text-to-speech (TTS) framework, a corpus of German utterances recorded with electromagnetic articulography (EMA) is resynthesized to provide training data for statistical models. The resynthesis is based on a measure of similarity between the original and resynthesized EMA trajectories, weighted by articulatory r...

 All patients should be screened for hepatitis B before starting treatment with direct-acting antivirals for hepatitis C.  Patients co-infected with hepatitis B and C who are treated with directacting antivirals should be monitored and treated according to current clinical guidelines. The recommendations from the EMA are available here: Direct-acting antivirals for hepatitis C: EMA confirms r...

Locally invasive non-metastatic persistent gestational trophoblastic tumours (PGTT) following a non-molar pregnancy occur very rarely. Non-metastatic tumours usually falls in low risk group in WHO scoring system based on prognostic factors. We report a case of high risk non-metastatic PGTT which followed a spontaneous first trimester abortion. Complete remission of the tumour was achieved by ch...

BACKGROUND An hCG regression curve has been used to predict the natural history and response to chemotherapy in gestational trophoblastic disease. We constructed hCG regression curves in high-risk gestational trophoblastic neoplasia (GTN) treated with EMA/CO and identified an optimal hCG level to detect EMA/CO resistance in GTN. MATERIALS AND METHODS Eighty-one women with GTN treated with EMA...

A geostatistical analysis of soil salinity in an agricultural area in the San Joaquin Valley included measurements of electrical conductivity of soil paste extract (EC3 and water content of soil samples supplemented by surface measurements of apparent electrical conductivity (EM”). Prediction of soil salinity at unsampled points by cokriging log@C3 and EMa is worthwhile because EM” measurements...

BACKGROUND The distinction of benign from malignant mesothelial proliferations in cytologic specimens can be problematic. In this study, the authors investigated the utility of immunohistochemical (IHC) markers in making this distinction. METHODS Archival paraffin-embedded cell blocks of pleural and peritoneal fluids from 52 patients with malignant mesothelioma (MM) and 64 patients with react...