Inactivity of the human cytomegalovirus (HCMV) major immediate-early regulatory region (MIERR), which is composed of promoter, enhancer, unique region, and modulator, is linked to lack of HCMV replication in latently infected cells and in other nonpermissive cell types, including human embryonal NTera2 carcinoma (NT2) cells. I refined the embryonal NT2 cell model to enable characterization of t...

Rhabdomyosarcoma (RMS) is a pediatric myogenic-derived soft tissue sarcoma that includes two major histopathological subtypes: embryonal and alveolar. The majority of alveolar RMS expresses PAX3-FOXO1 fusion oncoprotein, associated with the worst prognosis. RMS cells show myogenic markers expression but are unable to terminally differentiate. The Notch signaling pathway is a master player durin...

Hexamethylene bisacetamide (HMBA) induces in vitro the cytodifferentiation of PCC3/A/1 mouse embryonal carcinoma (EC) cells. In EC cells, actin is associated with surface structures but microfilament bundles are not seen. After 2 days of HMBA treatment, rounded EC cells are converted to flat adhesive ones with a developed cytoskeleton containing actin and tropomyosin. The ratio of actin to tota...

An immunohistologic study of 21 patients with germ cell tumors of the testis with m easured serum levels o f hum an chorionic gonadotropin (HCG) and alpha fetoprotein (AFP) was undertaken to correlate the various types of neoplasms with the presence of these tum or markers in the tissue and serum. The same immunoperoxidase technique was applied to 48 patients with m alignant germ cell tumors of...

The undifferentiated embryonal sarcoma of the liver is a rare tumor with poor prognosis, improved outcomes being reported more recently multimodality treatments. We report case 6-year-old girl an incidentally diagnosed and histologically proven localized liver. divergence between solid appearance at US cystic-like on CT/MRI, which has been attributed to presence myxoid component frequently desc...