The transcription factor Pax6 is an important regulator of development and cell differentiation in various organs. Thus, Pax6 was shown to promote neural development in the cerebral cortex and spinal cord, and to control pancreatic endocrine cell genesis. However, the role of Pax6 in distinct endocrine cells of the adult pancreas has not been addressed. We report the conditional inactivation of...

The aim of this study was to ascertain the morphological changes in the endocrine cell profile in the atrophic mucosa of mice with autoimmune gastritis induced by neonatal thymectomy and administration of carcinogenic chemical, N-methyl-N'-nitroN-nitrosoguanidine (MNNG). Proliferation of argyrophil cells, gastrin (Gl 7, G34) cells in areas of pseudopyloric metaplasia, enteric hormone (GIP, secr...

Endocrine therapy is the treatment of choice in hormone receptor-positive breast cancer. However, the effectiveness of these agents is limited by the development of drug resistance, ultimately leading to disease progression and patient mortality. Whilst pre-clinical cell models of acquired endocrine resistance have demonstrated a role for altered growth factor signalling in the development of a...

Background: The objective of this study was to investigate the effect of high and moderate summer ambient temperatures on testicular structures and endocrine profile of developing ram lambs. Materials and Methods: Twenty fall-born ramlambswere randomly divided into two groups: animalswere kept outdoor (n=10) under ambient temperature (31-50°C) or maintained indoor (26-32°C) from May to October ...

The transfer of genetic material into endocrine cells and tissues, both in vitro and in vivo, has been identified as critical for the study of endocrine mechanisms and the future treatment of endocrine disorders. Classical methods of gene transfer, such as transfection, are inefficient and limited mainly to delivery into actively proliferating cells in vitro. The development of viral vector gen...

The pancreas forms from dorsal and ventral buds that appear at the foregut-midgut junction starting at embryonic day (E)9.5 in the mouse. Over the subsequent 10 days of fetal development, these two apparently uniform clusters of epithelial cells differentiate into the cell types that compose the adult pancreas: the endocrine cells of the islets of Langerhans, the duct cells, and the exocrine ce...