Uterine tumors resembling ovarian sex cord tumors (UTROSCT) are rare uterine neoplasms. These tumors are usually benign, displaying a nodular or polypoid growth pattern; common occurrence is observed at the 4th to 6th decade of life. This entity is divided according to clinical behavior and pathological typical findings including different immunohistochemical staining. Traditionally type I tumo...

One of the exciting findings in recent cancer genome studies is the discovery of somatic mutations in several chromatin remodeling genes. These studies not only illuminate the emerging roles of chromatin remodeling in the pathogenesis of human cancer but also provide molecular genetic basis of aberrant epigenomic regulation as one of the key mechanisms driving cancer development. This is becaus...

AIM This article discusses the current use of volumetric modulated arc therapy (VMAT) techniques in clinical practice and reviews the available data from clinical outcome studies in different clinical settings. An overview of available literature about clinical outcomes with VMAT stereotactic/radiosurgical treatment is also reported. MATERIALS AND METHODS All published manuscripts reporting t...

wc studied the correlation between preoperative cervical cytology, postoperative clinicopathologic findings, and sites of metastasis from so surgically staged patients with endometrial carcinoma tliirty-faur patients (68%), liad normal cervical cytology, ami 16(32%) had malignant preoperative cervical cytology. malignant cervical smears were statistically correlated with surgical stage (p = 0.0...

background : endometrial cancer is the most common type of malignancy in female reproductive system and is the fourth common cancer after breast, lungs and colorectal cancers. our aim is to report epidemiology and frequency types of endometrial cancer and clinical staging and grading of this disease. methods : in this description and cross-sectional study, 75 patients with diagnosed endometrial...

Uterine serous carcinoma (USC) represents a clinically aggressive and highly malignant endometrial cancer. Initially distinguished from other types of primary endometrial adenocarcinoma in 1982, Hendrickson et al. [1] performed a pathologic review of 256 stage I endometrial cancers treated at Stanford University, with 26 of the cases revealing USC. Of these cases, 40% had deep myometrial invasi...

Endometrial calcification along with ossification is an uncommon clinical entity. Most of the cases are asymptomatic or present with secondary infertility. Endometrial ossification associated with repeated abortions has been reported very infrequently. Here we report a case of endometrial calcification with ossification  due to retained fetal bony tissue in a 38 year old symptomatic female havi...

Evidence is gradually accumulating about acquired somatic chromosome anomalies, particularly those of neoplasms. Unfortunately, control observations are almost entirely lacking. It is generally assumed that all the tissues of the body consist of cells with the normal karyotype as it is seen in cultured lymphocytes or fibroblasts, but this has not yet been shown to be the case. Even bone-marrow,...

BACKGROUND Tamoxifen increases the risk of endometrial cancer. However, few studies have produced reliable risk estimates by duration, dose, and recency of use, or addressed the prognosis of endometrial cancers in tamoxifen-treated women. METHODS We did a nationwide case-control study on the risk and prognosis of endometrial cancer after tamoxifen use for breast cancer. Information on tamoxif...

Endometrial cancer is the most common gynaecologic malignancy, usually diagnosed in postmenopausal women. However, an incidence rate of 2-14% of cases consisting of women under the age of 45 years old has been reported. Multiple reports have described the conservative treatment of this tumour in selected patients with the objective of preserving fertility. In this article, we review the literat...