نتایج جستجو برای: endothelin a receptor
تعداد نتایج: 13599043 فیلتر نتایج به سال:
The three reviewers all find the manuscript to be quite interesting and of value for the community, but raise (especially reviewers 1 and 3) a number of very serious and in part overlapping concerns on the limited experimental support for many of the main claims including limited mechanist insight, which inevitably impacts on the overall clinical relevance of the findings. They would also like ...
BACKGROUND Endothelin-1 signalling plays an important role in pathogenesis of pulmonary hypertension. Although different endothelin-A receptor antagonists are developed, a novel therapeutic option to cure the disease is still needed. This study aims to investigate the therapeutic efficacy of the selective endothelin-A receptor antagonist TBC3711 in monocrotaline-induced pulmonary hypertension i...
Doxorubicin is a frequently used anticancer drug, but its therapeutic benefit is limited by acute and chronic cardiotoxicity, often leading to heart failure. The mechanisms underlying doxorubicin-induced cardiotoxicity remain unclear. It was previously shown in men that doxorubicin leads to increased endothelin-1 plasma levels. In addition, cardiac-specific overexpression of endothelin-1 in mic...
Endothelin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Receptors [24]) are activated endogenous 21 amino-acid peptides endothelins 1-3 (endothelin-1, endothelin-2 and endothelin-3).
OBJECTIVES The purpose of this study was to investigate the regulation of beta-adrenergic agonist-induced apoptosis by endothelin-1 (ET-1) in cardiac myocytes. BACKGROUND Numerous hormonal factors including norepinephrine and ET-1 are activated in patients with heart failure. These factors may be involved in the positive and negative regulation of myocardial cell apoptosis observed in failing...
در این تحقیق روش حساس و نوینی جهت تشخیص بیماری آمیبیاز پیشنهاد شده است . اصول آزمایش بر این فرضیه استوار است که receptor های مخصوص آنتی ژن آمیب روی لنفوسیت های حساس شده میتوانند با این آنتی ژن ترکیب شوند. قبل از انجام آزمایش آنتی ژن آمیب را با آنزیم بتاگالاکتوزیداز conjugate میکنیم (a-z) . این آنزیم و همچنین ترکیب a-z در مجاورت substrate مخصوص خود (fdbg) fluorescein-d-b-galactopyronoside ایجاد ...
Experimental cerebral ischemia and organ culture of cerebral arteries result in the enhanced expression of endothelin ET(B) receptors in smooth muscle cells via increased transcription. The present study was designed to evaluate the involvement of calcium-calmodulin-dependent protein kinase (CAMK) in the transcriptional expression of endothelin receptors after organ culture. Rat basilar arterie...
The present study describes the pharmacological profile of ((E)-alpha-[[1-butyl-5-[2-[(2-carboxyphenyl)methoxy]-4-methoxy-phenyl ]-1H-pyrazol-4-yl]methlene]-6-methoxy-1,3-benzodioxole-5-propanoic acid) (SB 234551), a high-affinity, nonpeptide endothelin type A (ETA)-selective receptor antagonist. In human cloned ETA and endothelin type B (ETB) receptors, SB 234551 produced a concentration-depen...
Endothelin-1 is a potent vasoconstrictor produced by vascular endothelial cells. A recently cloned endothelin-1selective receptor, the endothelin-A receptor, mediates the vasoconstrictive action of endothelin-1. Because endothelin-1 also possesses mitogenic properties, it may play a role in regulating the proliferation of intimal smooth muscle cells. In this study, we analyzed the expression of...
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