Three-dimensional high-resolution imaging methods are important for cellular-level research. Optical coherence microscopy (OCM) is a low-coherence-based interferometry technology for cellular imaging with both high axial and lateral resolution. Using a high-numerical-aperture objective, OCM normally has a shallow depth of field and requires scanning the focus through the entire region of intere...

OBJECTIVE To introduce the use of optical coherence tomography with an operating microscope for intra-operative evaluation of the human larynx. METHODS A specially equipped operating microscope with integrated spectral domain optical coherence tomography apparatus was used during microlaryngoscopy. RESULTS Technical improvements in optical coherence tomography equipment (e.g. pilot beam, va...

optical coherence tomography (oct) uses the spatial and temporal coherence properties of optical waves backscattered from a tissue sample to form an image. an inherent characteristic of coherent imaging is the presence of speckle noise. in this study we use a new ensemble framework which is a combination of several multi-layer perceptron (mlp) neural networks to denoise oct images. the noise is...

Doppler optical coherence tomography (DOCT) is a valuable tool for depth-resolved flow measurements in tissue. However, DOCT is insensitive to flow in the direction normal to the imaging beam and requires knowledge of the phase of the demodulated signal. We present an alternative method of extracting flow information, using speckle of conventional amplitude optical coherence tomography images. ...

AIMS To describe a method for computerised alignment and averaging of sequences in optical coherence tomography (OCT) B-scans and to present selected clinical observations based on the resulting improvement in retinal imaging. METHODS A methodological study and retrospective investigation of selected cases. Five human subjects were included, one healthy subject, two patients with central sero...