Polyene antibiotics are a group of macrolide lactones that have antifungal activity against a wide variety of fungi. Administration of this group of antibiotics have recently increased due to the use of immunosuppressive drugs and increasing incidence of AIDS (1,2). Nystatin, the first polyene drug to be identified, is active against a wide variety of fungal pathogens including Candida, Aspergi...

Nanoparticles are a promising medication delivery method that can deliver drugs in controlled and targeted manner. They're made to release the medicine close proximity target tissue. Solid lipid nanoparticles (SLNs) new type of submicron-sized emulsion which solid replaces liquid (oil). The goal this study was create (SLN) containing pantoprazole (a proton pump inhibitor) improve drug's entrapm...

The glucose-1-phosphatase encoding gene (agp) of Pantoea agglomerans was sequenced and heterologously expressed in Escherichia coli. The enzyme showed very high homology to periplasmatic glucose-1-phosphatases of other members of the Enterobacteriaceae family. It was isolated from transformed Escherichia coli cells in a single step in high yields (32.3 ± 1.2 mg per litre of culture) by Ni-NT ag...

Objective: The objective of this study was to formulate an oral sustained release delivery system of ezetimibe mucoadhesive beads by ionic gelation technique based on sodium alginate used as a hydrophilic carrier in combination with carbopol 934P which acts as a rate modifier. Methods: Microbeads of ezetimibe were prepared using an easy method of ionotropic gelation by little modification while...

OBJECTIVE Complexation was investigated as an approach to enhance the entrapment of the cationic neurotherapeutic drug, galantamine hydrobromide (GH) into cationic chitosan nanoparticles (CS-NPs) for Alzheimer's disease management intranasally. Biodegradable CS-NPs were selected due to their low production cost and simple preparation. The effects of complexation on CS-NPs physicochemical proper...

The aim of this study was to understand and investigate the relationship between experimental factors and their responses in the preparation of ciprofloxacin hydrochloride based solid lipid nanoparticles. A quadratic relationship was studied by developing central composite rotatable design. Amount of lipid and drug, stirring speed and stirring time were selected as experimental factors while pa...

The purpose of this study was to improve the entrapment efficiency of the water-soluble drug metronidazole using internal cross-linking agents. Calcium pectinate beads containing metronidazole were prepared by dropping a drug-pectin solution in 1% and 5% (m/V) calcium chloride for surface cross-linked beads. For the core cross-linked beads calcium carbonate was dispersed in the drug-pectin solu...