The association between exposure to general anesthesia and dementia risk has been inconsistently reported across epidemiological studies. To better understand the association, we conducted a meta-analysis of epidemiological studies. PubMed and Embase were searched through April 2017. Random-effects models were used to pool association estimates. We further evaluated potential dose-response rela...

The in utero environment is a key determinant of long-term health outcomes; poor maternal metabolic state and placental insufficiency are strongly associated with these long-term health risks. Human epidemiological studies link maternal obesity and offspring cardiovascular disease in later life, but mechanistic studies in animal models are limited. Here, we review the literature pertaining to m...

The majority of epidemiological studies of breast feeding have been conducted in healthy, fullterm infant samples. Little is known about the incidence and correlates of breast milk feeding in preterm infants, particularly in those born outside of metropolitan areas. Therefore, hospital medical charts of 151 consecutively admitted preterm infants (</=34 weeks gestational age), in the US, were re...

This paper reports the findings obtained from an epidemiological study conducted on the Totos-a sub-Himalayan tribe who were at the verge of extinct in early 70's in the state of W.B. The place in which they live is not easily accessible to the outsiders. The present study investigated socio-demographical aspects and the level of psychiatric morbidity within the Toto community. The study had be...

Research aimed at deciphering the aetiology of obesity and the metabolic syndrome remains focused on two behavioural factors, namely diet and physical activity, even though epidemiologic research suggests that these two cornerstones of treatment and prevention account for only a small-to-moderate portion of the variance in these phenotypes. In recent years, this observation has prompted the int...

Several authors have suggested that it is safe to raise the health standard for nitrate in drinking water, and save money on measures associated with nitrate pollution of drinking water resources. The major argument has been that the epidemiologic evidence for acute and chronic health effects related to drinking water nitrate at concentrations near the health standard is inconclusive. With resp...

School of Public Health and Center for Health Promotion and Prevention Research, University of Texas at Houston, Houston, Texas; Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland; Department of Health Behavior and Health Education, University of North Carolina, Chapel Hill, North Carolina; School of Medicine, University of Colorado and Denver Vete...

Assessing vitamin and mineral supplement use is important because supplement use per se is an exposure of interest for the risk of several chronic diseases and because supplements contribute a large proportion of total (diet plus supplement) micronutrient intake, another important exposure in epidemiologic research. Unfortunately, little is known about methods for obtaining valid information ab...

BACKGROUND & OBJECTIVES There has been more than 100 per cent increase in incidence of stroke in low- and middle-income countries including India from 1970-1979 to 2000-2008. Lack of reliable reporting mechanisms, heterogeneity in methodology, study population, and small sample size in existing epidemiological studies, make an accurate estimation of stroke burden in India challenging. We conduc...

Omalizumab has demonstrated efficacy among patients with moderate to severe persistent allergic asthma, whose symptoms are inadequately controlled with other controller agents. This therapy is generally well tolerated, but there are some safety considerations, the most important of which is the rare, but potentially life-threatening, occurrence of omalizumab-associated anaphylaxis.In Canada, da...