The role of nitric oxide (NO) in epileptogenesis was studied in pentylenetetrazole (PTZ)-treated animals using in vivo and ex vivo EPR spectroscopy. NO generation was measured directly in the brain of a PTZ-induced mouse in vivo by an L-band EPR spectrometer. An elevation in NO production in the brain was observed during convulsions, and more NO was generated in the tonic seizure vs. the clonic...

To the Editor—It is common but erroneous practice among the general public to insert an object into the patient’s mouth during a convulsion to prevent him or her from biting the tongue or lips. This can actually cause more harm than good. Using a metal object, such as a spoon, may cause injury to the mouth or result in broken teeth, while objects like pencils or sticks may be bitten into pieces...

OBJECTIVES The relation between complicated early childhood convulsion (ECC) and adult epilepsy is unclear, although a history of complicated ECC is obtainable in half of adults with epilepsy associated with hippocampal sclerosis. It is not known if the ECC is a marker of pre-existing brain damage or is itself harmful to the developing brain. The objective of the study was to assess the extent ...

Background: Epilepsy is the 2nd greatest prevalent brain ailment after stroke, and a huge load on health system. Currently available antiepileptic drugs are associated with a lot of adverse effects and exhibit erratic pharmacological effects; hence it is crucial to explore newer anticonvulsant medications having better side effect profile and enhanced pharmacological effects because of the leng...

BACKGROUND Status epilepticus (SE) is a common, life threatening neurologic disorder that is essentially an acute, prolonged epileptic crisis. SE can represent an exacerbation of a pre-existing seizure disorder, the initial manifestation of a seizure disorder, or an insult other than a seizure disorder. OBJECTIVES To study the aetiology, clinical profile, and outcome of SE in pediatric age gr...

To the editor: Febrile convulsion is a common clinical problem in infancy or childhood that usually occurs at 3 months to 5 years of age and is associated with fever. In the United States, 3% to 5% of children experience febrile convulsion at <5 years of age; while in Japan, the frequency is 7%. However, hyperglycemia is proportionally frequent in the period of severe illnesses and may be the p...

purpose : retinoblastoma (rb) is a relatively common childhood tumor. in this report we discuss the clinical characteristics, treatments and outcome of the treated rb patients from a referral center in iran in order to understand this medical problem in our society. methods : a retrospective study was carried out on rb cases treated in farabi eye hospital since 1979 to 2007. the variables analy...