When dogs or cats get seizures, epileptic seizures and epilepsy are usually thought of. However, it is important to take into account the existence of that similar but do not belong (non-epileptic seizures). Nonepileptic occur suddenly, short-term, disappear as quickly they occur, recur have no etiology can be non-neurological neurological origin. Unlike non-epileptic a specific neural origin r...

background: epilepsy is a severe disorder of the central nervous system that predisposes  the person to recurrent seizures. fifty million people worldwide suffer from  epilepsy; after alzheimer's and stroke, it is the third widespread nervous disorder. objective: in this paper, an algorithm to detect the onset of epileptic seizures  based on the analysis of brain electrical signals (eeg) has be...

Non-epileptic seizures (NES) is a descriptive term for a diverse group of disorders that refer to paroxysmal events that can be mistaken for epilepsy, but are not due to an epileptic disorder. “Non-epileptic seizure” is the preferred term. As confirmed by Steven Schachter, MD in his 1966 survey of American epileptologists, the majority of respondents considers this to be the preferred term as o...

Epileptic seizure detection is commonly implemented by expert clinicians with visual observation of electroencephalography (EEG) signals, which tends to be time consuming and sensitive to bias. The epileptic detection in most previous research suffers from low power and unsuitability for processing large datasets. Therefore, a computerized epileptic seizure detection method is highly required t...

PURPOSE To elucidate the mechanisms that regulate p-glycoprotein (PGP) expression and function in pharmacoresistant epilepsy, we investigated the effect of an ETB receptor antagonist (BQ788) and a p38 mitogen-activated protein kinase (p38MAPK) inhibitor (SB202190) on intractable seizures in chronic epileptic rats. METHODS Lithium-pilocarpine-induced chronic epileptic rats were used in the pre...

The pattern of epileptic seizures is often considered unpredictable and the interval between events without correlation. A number of studies have examined the possibility that seizure activity respects a power-law relationship, both in terms of event magnitude and inter-event intervals. Such relationships are found in a variety of natural and man-made systems, such as earthquakes or Internet tr...

The epileptic network is characterized by pathologic, seizure-generating 'foci' embedded in a web of structural and functional connections. Clinically, seizure foci are considered optimal targets for surgery. However, poor surgical outcome suggests a complex relationship between foci and the surrounding network that drives seizure dynamics. We developed a novel technique to objectively track se...

The "disinhibition" hypothesis contends that (1) seizures begin when granule cells in the dentate gyrus of the dorsal hippocampus are disinhibited and (2) disinhibition occurs because GABAergic interneurons are excessively inhibited by other GABAergic interneurons. We tested the disinhibition hypothesis using the experimental model that inspired it-naturally epileptic Mongolian gerbils. To dete...

Synchronization of local and distributed neuronal assemblies is thought to underlie fundamental brain processes such as perception, learning, and cognition. In neurological disease, neuronal synchrony can be altered and in epilepsy may play an important role in the generation of seizures. Linear cross-correlation and mean phase coherence of local field potentials (LFPs) are commonly used measur...

Accumulation of abnormally integrated, adult-born, hippocampal dentate granule cells (DGCs) is hypothesized to contribute to the development of temporal lobe epilepsy (TLE). DGCs have long been implicated in TLE, because they regulate excitatory signaling through the hippocampus and exhibit neuroplastic changes during epileptogenesis. Furthermore, DGCs are unusual in that they are continually g...