Heart rate changes are common in epileptic and non-epileptic seizures. Previous studies have not adequately assessed the contribution of motor activity on these changes nor have evaluated them during prolonged monitoring. We retrospectively evaluated 143 seizures and auras from 76 patients admitted for video EEG monitoring. The events were classified according to the degree of ictal motor activ...

Study of Cannon et aI. Cannon and colleagues (2) demonstrated inappropriate arteriolar constriction in patients with atyp ical chest pain and msignificant coronary artery disease. These cases . which may represent a distin ct syndrome. offer a number of lines of evidence. First. Cannon et al. demon strated for the first time that . 'v asoconstrictor stimuli act ing at the arter iolar level can ...

Hemimasticatory spasm is a rare neurologic disorder characterized by unilateral, paroxysmal involuntary contraction of the masticatory muscles. It can be confused with other unilateral facial spasms. In this report, we present two patients with hemimasticatory spasm who were initially misdiagnosed with other disorders. The first patient was a 54-year-old man with a 9-year history of right facia...

Objective: To investigate the association between primary hemifacial spasm and arterial hypertension. Subjects: 114 patients with primary hemifacial spasm and 228 neurological controls, matched for age, sex, and referral centre, were recruited during an 18 month period from consecutive outpatients attending two neurological institutions. Design: The association between exposure variables and ca...

BACKGROUND/OBJECTIVE Guaifenesin, an over-the-counter (OTC) expectorant, has exhibited muscle relaxant effects preclinically and clinically. This proof-of-principle study explored whether OTC doses of guaifenesin can provide relief from acute upper back, neck, or shoulder muscle spasm and pain. METHODS This multicenter, placebo-controlled, repeat-dose, parallel study randomly assigned adults ...

Coronary artery spasm was first proposed as a cause of spontaneous, recurring angina1 attacks over a century ago (1). Because this brilliant clinical intuition could not be demonstrated at postmortem study, it fell into progressive disrepute until, in the early 1950s coronary artery spasm was considered “the resort of the diagnostically destitute” (2). In 1959, the notion of coronary artery spa...

BACKGROUND Risk factors for pure coronary spasm are not known. Clinical observations have pointed to cigarette smoking, a known risk factor for obstructive coronary artery disease. METHODS AND RESULTS We conducted a case-neighborhood control study of premenopausal women, a population segment with the lowest prevalence of obstructive coronary artery disease. The cases were 21 premenopausal wom...

OBJECTIVE To investigate the association between primary hemifacial spasm and arterial hypertension. SUBJECTS 114 patients with primary hemifacial spasm and 228 neurological controls, matched for age, sex, and referral centre, were recruited during an 18 month period from consecutive outpatients attending two neurological institutions. DESIGN The association between exposure variables and c...

Background Reproductive dysfunction and endocrine disorders are common among men with complex partial seizures of temporal lobe origin. Diminished sexual desire and responsiveness along with decreased libido and less orgasm are frequently described in men with temporal lobe epilepsy (TLE). It appears that the reduced fertility in epileptic men is accompanied by erectile dysfunction and abnormal...

Coronary artery spasm is an uncommon, but well recognized, etiology for acute myocardial infarction. However, cardiogenic shock with myocardial infarction resulting from simultaneous multiple coronary artery spasm has been rarely reported, and not in Korea. Recently, we experienced such a case in a 50-year-old Korean man without previous diagnosis of variant angina. The patient, hospitalized fo...