An in vitro biorelevant gastrointestinal transfer (BioGIT) system was assessed for its ability to mimic recently reported albendazole concentrations in human upper small intestine after administration of free base suspensions to fasted adults in absence and in presence of supersaturation promoting excipients (hydroxypropylmethylcellulose and lipid self-emulsifying vehicles). The in vitro method...

Lipases are a group of enzymes naturally endowed with the property of performing reactions in aqueous as well as organic solvents. The esterification reactions using lipase(s) could be performed in water-restricted organic media as organic solvent(s) not only improve(s) the solubility of substrate and reactant in reaction mixture but also permit(s) the reaction in the reverse direction, and oft...

Phase equilibrium experimental data for the CO2/glycerol system are reported in this paper. The measurements were performed using an in situ FT-IR method for temperatures ranging from 40 C to 200 C and pressures up to 35.0 MPa, allowing determination of the mutual solubility of both compounds. Concerning the CO2 rich phase, it was observed that the glycerol solubility in CO2 was extremely low (...

The improvement of knowledge about the toxicity and even processability, and stability of quantum dots (QD) requires the understanding of the relationship between the QD binding head group, surface structure, and interligand interaction. The scanned stripping chronopotentiometry and absence of gradients and Nernstian equilibrium stripping techniques were used to determine the concentration of C...

The need for accurate modeling of fluid-mineral processes over wide ranges of temperature, pressure and composition highlighted considerable uncertainties of available property data and equations of state, even for the CO2 + H2O binary system. In particular, the solubility, activity, and ionic dissociation equilibrium data for the CO2-rich phase, which are essential for understanding dissolutio...

The formation of precipitates during thermal processing of microalloyed steels greatly influences their mechanical properties. Precipitation behavior varies with steel composition and temperature history and can lead to beneficial grain refinement or detrimental transverse surface cracks. This work presents an efficient computational model of equilibrium precipitation of oxides, sulfides, nitri...

in this study, the ion association phenomenon in the saturated solution of kcl in the mixed solvent(methanol+water) was studied. the solubility of this compound in the mixed solvent (methanol+water by value percent of methanol = 60%), and in the presence of various molarities of nano3 wasdetermined by the solvent evaporation method at 25.0°c. the results enable us to estimate the valueof thermo...

Experimental studies involving equilibrium solubility and dissolution/precipitation rates were initiated on aluminum hydroxide phases prevalent under geothermal reservoir conditions. A large capacity, hydrogen-electrode concentration cell (HECC) was constructed specifically for this purpose. This cell provides continuous, accurate in situ pH measurements of solid/solution mixtures to 295C with ...

Phase equilibrium and glass formation between AsS ErS compounds were studied by methods of physicochemical analysis: differential-thermal (DTA), X-ray phase (XRD), microstructural analysis (MSA), as well measuring microhardness density. The T-x diagram the AsS–ErS system was constructed. It has been established that is quasi-binary, eutectic type characterized chemical compound ErAsS2. ErAsS2 f...

The high stability of zirconium dioxide in aqueous environments is known and demonstrated, this property strongly used nuclear industry to ensure the long term storage wastes. However, only upper limits its solubility are reliably lower linked very well crystallized ZrO2 much less assessed. Indeed, low dissolution rate zirconia makes measurements a challenging task. To overcome, S/V ratios nano...