The estrogen receptor (ER) is a classical protein that plays crucial role in mediating multiple signaling pathways various target organs. It has been shown ER-targeting therapies inhibit breast cancer cell proliferation, enhance neuronal protection, and promote osteoclast formation. Several drugs have designed to specifically ER ER-positive (ER+) cancer, including selective modulators (SERM) su...

There is a rich literature about the temporal conjunctions before/after, but at the time I gave the talk that underlies this paper I was not aware of any analysis of the temporal comparatives früher/später ‘earlier/later’, which may be used to express similar states of affairs, but are constructed differently. Recently I got acquainted with the del Prete’s thesis about It. prima/dopo, which ana...

Cancer Phototherapy The endoplasmic reticulum (ER) plays an important role in protein synthesis, processing and secretion. ER-targeting phototherapy significantly amplifies ER stress, promotes tumor antigen release, elicits a robust immunogenic cell death. In article number 2202728 by Weidong Wang, Junping Shenglin Luo, co-workers, small molecular heptamethine cyanine photosensitizer with binit...