this paper presents a 54-year-old female with lupus whom severe anaemia due to pure red cell aplasia (prca) was the first manifestation. there was seven years interval between prca onset and diagnosis of lupus. thymectomy due to thymoma had been carried out six years before but anaemia sustained. hypothyroidism and hypoparathyroidism were other associated diseases. severe anaemia and the need f...

OBJECTIVE To provide an up-to-date review of the etiology, epidemiology, clinical features, diagnostic findings, and treatment options for systemic lupus erythematosus (SLE). DATA SOURCES A PubMed search of English language articles using a combination of words: elderly, systemic lupus erythematosus*, late onset systemic lupus erythematosus*, etiology, screening, diagnosis, or treatment to id...

3. Thatayatikom A, White AJ. Rituximab: A promising therapy in systemic lupus erythematosus. Autoimmun Rev. 2006;5:18--24. 4. Boye J, Elter T, Engert A. An overview of the current clinical use of the anti-CD20 monoclonal antibody rituximab. Ann Oncol. 2003;14:520--35. 5. Cohen SB. Targeting the B cell in rheumatoid arthritis. Best Pract Res Clin Rheumatol. 2010;24:553--63. 6. Fatourechi MM, el-...

We describe a 34 year old woman who presented initially with a progressive pseudobulbar palsy. A delay of five months occurred before a diagnosis of cerebral systemic lupus erythematosus was made. Currently available investigations for cerebral systemic lupus erythematosus are evaluated and the need for an easily performed specific diagnostic test is discussed.

Chorea may occur as a neurological manifestation of systemic lupus erythematosus and is often associated with detection of antiphospholipid antibodies. No evidence of chorea as a sign of lupus activity has been established. We describe a patient with systemic lupus erythematosus associated with antiphospholipid antibodies who developed chorea, which has been considered a sign of lupus activity.

INTRODUCTION Pigmented villonodular synovitis is a rare disease of unknown etiology mostly affecting the knee and foot. Until now an association with autoimmune diseases has not been reported. CASE PRESENTATION The diagnosis of systemic lupus erythematosus was made in a 15-year-old Caucasian girl based on otherwise unexplained fatigue, arthralgia, tenosynovitis, leukopenia, low platelets and ...

Significant differences in both specificity and avidity of anti-DNA antibodies were observed in the sera of groups of patients with active systemic lupus erythematosus glomerulonephritis, active systemic lupus erythematosus without nephritis, and in IgG eluates obtained by DNAase digestion of isolated glomeruli from glomerulonephritic kidneys. With methylated albumin-kieselguhr fractionated 3H-...

3. Thatayatikom A, White AJ. Rituximab: A promising therapy in systemic lupus erythematosus. Autoimmun Rev. 2006;5:18--24. 4. Boye J, Elter T, Engert A. An overview of the current clinical use of the anti-CD20 monoclonal antibody rituximab. Ann Oncol. 2003;14:520--35. 5. Cohen SB. Targeting the B cell in rheumatoid arthritis. Best Pract Res Clin Rheumatol. 2010;24:553--63. 6. Fatourechi MM, el-...