Familial Mediterranean fever (FMF) is a periodic autoinflammatory disease characterized by chronic inflammation. This study investigated the relationship between acute-phase reactants and gene mutations in attack-free periods of childhood FMF. Patients diagnosed with FMF were divided into four groups based on genetic features: no mutation, homozygous, heterozygous, and compound heterozygous. Th...

B complex vitamins play an important role in the metabolism of carbohydrates, proteins and fats. The aim of this study was to determine the effects of B complex vitamins administered by exogenous route on rumen protozoa, hematological and blood biochemical parameters in clinically healthy cattles. Thirty cattles aged between 6 to 18 months, and breeding in Afyonkarahisar Province and surroundin...

A single somatic mutation, V617F, in Janus kinase 2 (JAK2) is one of the causes of myeloproliferative neoplasms (MPNs), including primary myelofibrosis, and the JAK2V617F mutant kinase is a therapeutic target in MPN. However, inhibition of wild-type (WT) JAK2 can decrease the erythrocyte or platelet (PLT) count. Our selective JAK2 inhibitor, NS-018, suppressed the growth of Ba/F3 cells harborin...

A 56-year-old Japanese man with liver cirrhosis (LC) due to hepatitis C virus was admitted to our hospital for radiofrequency ablation of residual tumor following lusutrombopag administration. Laboratory tests revealed thrombocytopenia and leukopenia. The patient's LC was managed, and he was classified as Child-Pugh A. After admission, lusutrombopag was administered for 7 days. The platelet cou...

Malarial parasites are expected to induce haematological alterations but reports on changes in haematological parameters during malaria among adults in Southwest Nigeria are not well documented. To investigate the effect of acute malaria on some haematological indices, a sample of 5 ml of venous blood was drawn from each of 671 adults with acute malarial infection and 523 apparently healthy sub...

BACKGROUND Frequency and classification of anemia in terms of regeneration status and erythrocyte indices are not well described in cats. OBJECTIVE To determine frequency and regenerative status of anemia in samples from adult cats, to assess the sensitivity and specificity of macrocytosis and hypochromasia for detecting regenerative anemia (RA), and to evaluate the association of anemia with...

BACKGROUND Diabetes has been associated with several complications occasioned by oxidative stress. Thus, in treatment of the condition, these complications must also be taken into consideration. This study evaluates the effect of Cnidoscolus aconitifolius complications of diabetes induced by alloxan, on haematology and sperm morphometry using the Wistar rats. METHODS Diabetes was induced in 2...

OBJECTIVE To present the mesalamine-induced acute exacerbation of symptoms and inflammatory markers in children with Crohn's disease (CD). CLINICAL PRESENTATION AND INTERVENTION Three children who presented with CD had acute exacerbation of colitis symptoms or elevated inflammatory markers when mesalamine was added to treatment while tapering/ceasing steroid treatment. While on steroid treatm...

Aim. To assess the effect of iron-rich humic substances on hematological parameters in acute post-hemorrhagic and iron deficiency anemia. Materials methods. for study were samples active pharmaceutical ingredients based (Fe(III) hydroxide complexes with polymaltose): HA-Fe 3+ , HA-PMFe FA-Fe FA-PM-Fe . The anti-anemic activity was studied 53 female Wistar rats conventional rat line model posthe...

a 90 day study was conducted on twenty four indigenous non-descript goats allocated into four groups. they were fed ad libitum basal complete feed constituted rice straw: rhea (60:40) grass hay and concentrate mixture @ 250/animal/day. basal complete feed contain 11.07% dcp and 54.21% tdn. groups were control (t0) basal diet without polyherbal supplementation, treatment 1 (t1) diet with ruchama...