To develop an effective technology for conversion of inorganic arsenic to methylated organic compounds by using microorganisms, we have searched microorganisms the methylation ability that are adequately applicable detoxification process. As a result, isolated arsenic-methylating bacteria Cellulomonas sp. K31.

Arsenic uptake and translocation studies on xylem sap focus generally on the concentration and speciation of arsenic in the xylem. Arsenic impact on the xylem sap metabolite profile and its production during short term exposure has not been reported in detail. To investigate this, cucumbers were grown hydroponically and arsenate (As(V)) and DMA were used for plant treatment for 24 h. Total arse...

Arsenic-containing lipids (arsenolipids) are novel natural products recently shown to be widespread in marine animals and algae. Research interest in these arsenic compounds lies in their possible role in the membrane chemistry of organisms and, because they occur in many popular seafoods, their human metabolism and toxicology. Progress has been restricted, however, by the lack of standard arse...

Although arsenic trioxide (arsenite, As(III)) has shown a remarkable efficacy in the treatment of acute promyelocytic leukemia patients, multidrug resistance is still a major concern for its clinical use. Multidrug resistance-associated protein 4 (MRP4), which belongs to the ATP-binding cassette (ABC) superfamily of transporters, is localized to the basolateral membrane of hepatocytes and the a...

for the presentation at the EU-RL-ISS workshop 7-8 October 2013 (Rome, Italy) Arsenic speciation in food – current status on standardization of methods for specific determination of inorganic arsenic Jens J. Sloth, senior scientist, phd National Food Institute,Technical University of Denmark Division of Food Chemistry Mørkhøj Bygade 19, DK-2860 Søborg Email: [email protected] Arsenic (As) is a u...

The coordination environment and the redox speciation of arsenic in a newly discovered arsenic hyper-accumulating fern (Pteris vittata L) were investigated by X-ray absorption spectroscopy. This method allowed us to probe arsenic directly, i.e., with minimal sample preparation. The results indicate that arsenic is predominantly accumulated as As(III) in the leaves. XANES and EXAFS results show ...

Worldwide, millions of people are exposed to arsenic in drinking water that exceeds the World Health Organization standard of 10 microg/liter by as much as 50-300-fold, yet little is known about the molecular basis for arsenic excretion. Here we show that transport of arsenic into bile depends on the MRP2/cMOAT transporter and that glutathione is obligatory for such transport. Using reversed ph...