David W. Newton, BS, PhD, FAPhA Bernard J. Dunn School of Pharmacy Shenandoah University Winchester, Virginia Lawrence A. Trissel, BS, RPh, FASHP M.D. Anderson Cancer Center The University of Texas Houston, Texas Editor’s Note In January 2004, Chapter <797> in the United States Pharmacopeia 27 became the first practice standards for sterile pharmacy compounding in US history that may be enforce...

Verapamil is used in high doses for the treatment of cluster headache. Verapamil has been described as a P-glycoprotein (P-gp, ABCB1) substrate. We wished to evaluate in vitro whether co administration of a P-gp inhibitor with verapamil could be a feasible strategy for increasing CNS uptake of verapamil. Fluxes of radiolabelled verapamil across MDCK II MDR1 monolayers were measured in the absen...

PURPOSE A preliminary investigation was conducted to evaluate and compare the effectiveness of two closed-system products in preventing contamination of typical pharmacy workplace surfaces with cyclophosphamide during simulated hazardous drug preparation activities in a controlled laboratory setting. METHODS Two separate trials simulating hazardous drug compounding using cyclophosphamide were...

BACKGROUND Previous studies have identified medication errors in preparing and administering intravenous medicines of 13-84% in hospitals in individual countries. OBJECTIVE To compare the effect of the design and implementation of systems for the preparation and administration of intravenous therapy in hospitals in three European countries on the number of observed medication errors. To gain ...

In the present investigation an attempt has been made to explore traditional medicinal knowledge of plant species used against rheumatism by the Bhoxa tribe of district Dehradun. An ethnobotanical survey was carried out among the tribal people in all seasons to collect the relevant information about the medicinal uses of wild plants. Frequent field trips were made for the collection of plant sp...

A novel compounding vehicle (RECURA) has previously been proven to penetrate the nail bed when compounded with the antifungal agent miconazole or fluconazole, providing for an effective treatment for onychomycosis. In this study, miconazole and fluconazole were compounded separately in RECURA compounding cream, and they were tested at different time points (0, 7, 14, 28, 45, 60, 90, and 180 day...

One of the indispensable pieces of information a compounder needs with every pharmaceutical ingredient chemical is the Certificate of Analysis. In fact, it is needed with every different lot of the material, since variations from lot to lot in chemicals can be significant. This article briefly explains what a Certificate of Analysis contains, how to use it in compounding, and provides several e...

All Portuguese community pharmacies have a compounding laboratory and minimum equipment for the preparation of nonsterile (traditional) compounded medicines, but a few community pharmacies specialize in compounding. At Farmácia Lordelo, the most frequently dispensed compounded medicines are oral liquids for pediatrics and multi-drug, semi-solid preparations for dermatology patients. The majorit...

Morphological productivity (roughly: the readiness with which a word formation process forms new words) has long been one of the central mysteries of morphology. There are many detailed qualitative descriptions of word formation processes that list the restrictions for the possible bases for an affix (like the restriction that -able attaches to verbs in English) or the restrictions on a given c...