background: exposure to endogenous hormones such as estrogen is known as a lifetime breast cancer (bc) risk factor. polymorphisms in genes that are involved in the steroidogenic process, such as cytochrome p450c17alpha ( cyp17) , affect individuals’ susceptibility to bc. in iran, the highest incident of bc is among young women. this study aimed to find prevalence of single nucleotide polymorphi...

Breast cancer is the most common invasive cancer in women globally, and it affects more than 1 million women worldwide each year. It is a preventable disease in part, and primary care providers and public health programs play a key role in providing cancer preventive care. There are several health behaviors that may reduce the risk of breast cancer, including prolonged lactation; regular physic...

Present study was undertaken to examine the extent of Polycyclic Aromatic Hydrocarbons (PAHs) contamination in neighbourhood lithospheric environment of landfill site situated in eastern outer edge of Kolkata metropolitan city in West Bengal, India, along with its sources identification, spatial distribution and probabilistic cancer risks to residents. The collection and analytical tests were p...

Numerous studies have observed reduced breast cancer risk with increasing levels of physical activity, yet these findings have been inconsistent about optimal times of activity and effect modification by other factors. We investigated the association between recreational and occupational physical activity and breast cancer risk in a population-based case-control study in Massachusetts, New Hamp...

This paper reviews studies on the adverse health effects of exposure to metals, using arsenic and cadmium as examples. The carcinogenic potential of arsenic has been studied in various settings. Inhalation is clearly related to the development of lung cancer in (copper) smelting and arsenical pesticide manufacturing, and also in heavily exposed wine merchants who had an additional source of exp...

BACKGROUND Existing data suggest that physical activity reduces colon cancer risk, but the association is not consistently observed in women. One potential explanation for this inconsistency is that hormone therapy, which is associated with lower colon cancer risk, acts as a modifier of the physical activity/colon cancer relationship. METHODS Participants in the California Teachers Study (N =...

Psoriasis is a common inflammatory condition involving the skin, scalp, nails and joints. It significantly increases the risk of cardiovascular events and death in those affected, above Framingham Risk Score (FRS) prediction alone 1 . There is a dose-response element; those with the most severe psoriasis (assessed by the psoriasis area severity index (PASI) score) are at the greatest risk. A UK...

OBJECTIVES To quantify the life years gained and financial savings by preventing a case of occupational cancer. METHODS The authors retrieved data from the Taiwan Cancer Registry and linked them with the National Mortality Registry to estimate the survival functions for major occupational cancers: lung, pleural mesothelioma, urinary bladder and leukaemia. Assuming a constant excess hazard for...