Colorectal cancer (CRC) metastasis to the thyroid gland is rare. Here wereport a 45 yr-old man in western Iran referred to Hematology Clinic, Kermanshah city, Iran in March 2014 with complaint of exertional dyspnea, multi-nodular goiter as well as complaint of exertional dyspnea, and multi-nodular goiter. His history included a low anterior resection of rectum in 9 months ago for a high-risk st...

The aim of this study was to test the hypothesis that neural respiratory drive, measured using diaphragm electromyogram (EMGdi) activity expressed as a percentage of maximum (EMGdi%max), is closely related to breathlessness in chronic obstructive pulmonary disease. We also investigated whether neuroventilatory uncoupling contributes significantly to breathlessness intensity over an awareness of...

Effective management of dyspnea in chronic obstructive pulmonary disease (COPD) requires a clearer understanding of its underlying mechanisms. This roundtable reviews what is currently known about the neurophysiology of dyspnea with the aim of applying this knowledge to the clinical setting. Dyspnea is not a single sensation, having multiple qualitative descriptors. Primary sources of dyspnea i...

A 71-year-old male presented with progressive exertional breathlessness and cough for the last four years. His breathlessness aggravated after a heavy meal and on lying down. He was a smoker, but had no co-morbidities. He did not remember any major trauma or surgery. Examination of the respiratory system revealed mediastinal shift to the left, diminished breath sounds over the whole of the righ...

Shortness of Breath 2014; 3 (4): 190-200 ly activity, reducing dyspnoea and fatigue, and enhancing the quality of life and muscle strength. So, the final message from the available literature reports is a strong recommendation to adopt exercise training and cardiopulmonary rehabilitation programs for any patient suffering from exertional dyspnoea and fatigue. Many questions remain unanswered re...

Exercise intolerance is a feature of chronic heart failure (CHF). We hypothesized that excessive loading of the respiratory muscle pump might contribute to exertional breathlessness. One marker of excessive muscle-loading is slowing of maximum relaxation rate (MRR) and, therefore, to test our hypothesis, we investigated the effect of exhaustive treadmill walking on inspiratory muscle MRR in pat...

, Pr. Harrold: This man was 68 when he died. He was a gentlemen's outfitter. Before illness he had had two hernia repairs, and during the 1914-1918 war he had had afew injuries to the arms and legs. He had also had a brief episode of jaundice. His final illness began in the summer of 1962. He died in the summer of 1963. In J962 he noticed the onset of progressive mild exertional dyspnoea. In No...

STUDY OBJECTIVES We have previously shown that tiotropium at 18 mug reduces lung hyperinflation and dyspnea during exercise and improves exercise tolerance in patients with COPD. The present study was designed to gain further insight into the duration of improvements. DESIGN, PATIENTS, AND INTERVENTIONS A randomized, double-blind, placebo-controlled, parallel-group study was conducted in 261 ...