background: multiple sclerosis (ms) is a neurological disease with a variety of signs and symptoms. exercise therapy has been shown to improve physical functions in ms. however, questions about an optimal exercise therapy remain. in this regard, we suggest a combined exercise therapy including aerobic and resistance exercises for ms patients. the study is designed to observe, test and compare t...

BACKGROUND Magnetic resonance imaging (MRI) is the best biomarker of inflammatory disease activity in relapsing remitting Multiple Sclerosis (RRMS) so far but the association with disability is weak. Appearance of new MRI-lesions is used to evaluate response to immunotherapies in individual patients as well as being the most common primary outcome in phase-2 trials. Measurements of brain atroph...

This study investigates the application of classification methods for the prognosis of future disability on MRI-detectable brain white matter lesions in subjects diagnosed with clinical isolated syndrome (CIS) of multiple sclerosis (MS). For this purpose, MS lesions and normal appearing white matter (NAWM) from 30 symptomatic untreated MS subjects, as well as normal white matter (NWM) from 20 h...

OBJECTIVE The aim of this study was to evaluate the association between different disability states in patients with multiple sclerosis (MS) as determined by the expanded disability status scale (EDSS) and dental-periodontal measures. SUBJECTS AND METHODS Eighty patients with MS (64 females and 16 males) were included in this study. Data on MS types, attack frequency, disease duration, EDSS s...

background: disability is the most important determinants of disease course, treatment and rehabilitation outcomes and consequently the quality of life in patients with multiple sclerosis. the aim of the present study was to determine the relationship of disability and quality of life in multiple sclerosis patients.   methods: this cross-sectional study was performed on 325 patients referred to...

Background: Mesenchymal stem cell therapy has been used in multiple sclerosis (MS) in order to modulate the course of the disease in previous studies. One of the major concerns in such cases is long term safety or efficacy of this type of therapy. Objectives: This study was conducted to report the clinical status of five patients with secondary progressive multiple sclerosis and one patient wit...

The association between clinical outcomes and abnormal susceptibility-weighted imaging (SWI)-filtered phase, indicative of increased iron content, as well as atrophy, was investigated in the subcortical deep-gray matter (SDGM) of multiple sclerosis (MS) patients. 149 relapsing-remitting (RR) and 61 secondary-progressive (SP) MS patients underwent SWI on a 3T scanner. Mean phase of the abnormal ...

BACKGROUND AND PURPOSE The influence of apolipoprotein E (ApoE) polymorphism on clinical severity of multiple sclerosis (MS) is still controversial. Cigarette smoking has been suggested to influence the progression of disability in these patients. In this study, we aimed to investigate whether an interaction of smoking with the ApoE polymorphism influences the progression of disability in MS pa...

OBJECTIVE To address the disability impact on fine hand motor functions in patients with Multiple Sclerosis (MS) by quantitatively measuring finger opposition movements, with the aim of providing a new "score" integrating current methods for disability assessment. METHODS 40 MS patients (Expanded Disability Status Scale (EDSS): 0-7) and 80 healthy controls (HC) performed a repetitive finger-t...

BACKGROUND Mesenchymal stem cells (MSCs) with their potential to differentiate into mesodermal and non-mesodermal lineages have several immunomodulatory characteristics. These properties make them promising tools in cell and gene therapy. OBJECTIVE To evaluate the potential therapeutic applications of autologous MSC in improving clinical manifestations of MS patients. METHODS Ten patients w...