Out of 100 patients with chronic heart block 16 had one or more autoimmune disorders-namely, vitiligo (5,) hypothyroidism (4), Graves's disease (1), pernicious anaemia (2), and diabetes mellitus (9). All these disorders occurred with greater frequency than normal and were more prevalent than in a group of hospital inpatients of comparable age. Autoantibodies were not increased. We suggest that ...

We describe a young woman with primary adrenal insufficiency, hypoparathyroidism (autoimmune polyglandular syndrome type 1), Graves disease, vitiligo, and alopecia universalis. Five years after the diagnosis, she presented with recurrent ophthalmological and neurological disorders as features of Vogt-Koyanagi-Harada syndrome. A marked therapeutic response was noted on systemic high-dose cortico...

Vitiligo is a chronic autoimmune skin disorder that re­sults as depigmented patches of the due to loss melanocytes. Although disease often asymptomatic, it impairs patients` quality life. The aim this study was assess factors associated with negative impact on life in terms clinical features, pa­tients` functioning and emotional status Lithuania. An observational, cross-sectional consisted 131 ...

Vitiligo is an autoimmune disease of the skin causing disfiguring patchy depigmentation of the epidermis and, less commonly, hair. Therapeutic options for vitiligo are limited, reflecting in part limited knowledge of disease pathogenesis. Existing mouse models of vitiligo consist of hair depigmentation but lack prominent epidermal involvement, which is the hallmark of human disease. They are th...

vitiligo vulgaris is a pigment disorder as the lack of skin pigmentation which its most prevalent cause is autoimmune. vitamin d has various effects on the natural and acquired immune of the body because of its effectiveness on the t cells and b cells, macrophages and dendritic cells.the object of this study was assessment of the vitamin d in patients with vitiligo vulgaris in dermatologic clin...

Vitiligo is brought on by functional melanocyte loss and manifests as white maculae that may cover the whole body's skin. There a genetic background in pathogenesis of vitiligo. Polymorphisms different parts catalase gene affect disease activity result less catalase, thus, accumulation hydrogen peroxide, one oxidative factors damage melanocytes. We evaluated CAT 262 polymorphism vitiligo patien...

Depigmenting skin lesions have a limited differential in dermatology. Although the depigmenting process of vitiligo can be clinically striking, it is at best a cosmetic issue, and may or may not be indicative of other pertinent autoimmune process. However, the early diagnosis of lichen sclerosus (LS) is of the utmost importance, since it is associated with potentially severe pain, disfigurement...

In an unprecedented effort in the field of vitiligo, a global consensus resulted on a suggested new classification protocol for the disease. The main histopathological finding in vitiligo is the total absence of functioning melanocytes in the lesions, while the inflammatory cells most commonly found on the edges of the lesions are CD4+ and CD8+ T lymphocytes. Physical and pharmacological treatm...

Melanocytes in patients with vitiligo possess intrinsic abnormalities that contribute to its pathogenesis. Regazzetti et al. report that CXCL10 expression reflects subtle inflammation in normal-appearing skin but not in stable depigmented lesions, supporting the hypothesis that melanocytes themselves initiate autoimmune inflammation prior to clinically evident disease. In addition, they find th...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background : vitiligo is an acquired, autoimmune melanocytic disorder characterized by circumscribed depigmented macules and patches. it affects approximately 0.5-2% of the general population worldwide. many medical treatments have been attempted with partial success, but there has been no previous trial on the combination...