the objective of the present study was to design an oral controlled drug delivery system for sparingly soluble diclofenac sodium (dcl) using guar gum as triple-layer matrix tablets. matrix tablet granules containing 30% (d1), 40% (d2) or 50% (d3) of guar gum were prepared by the conventional wet granulation technique. matrix tablets of diclofenac sodium were prepared by compressing three layers...

     The purpose of this work was to develop once daily sustained release (SR) matrix tablets of naproxen, an anti-inflammatory agent. The tablets were prepared by wet granulation method along with hydrophilic matrix materials like Methocel K 15M CR and Methocel K 100M CR. The granules were evaluated for bulk density, angle of repose, compressibility index, total porosity and drug content. The ...

In the past decade, many strategies have been developed to enhance oral drug delivery. Different techniques were investigated, amongst those the use of permeation enhancers such surfactants and biodegradable polymers were studied more extensively. Chitosan and its derivatives have been studied as permeation enhancer. The aim of the current study was to develop a nanoparticulate system based on ...

In this study, the effects of various hydrophilic (HPMC and Carbopol 971) and plastic (Ethylcellulose and Eudragit RL100) polymers on the release profile of diltiazem HCl from matrix tablets were evaluated in-vitro. For this purpose, tablets containing 60 mg of diltiazem HCl along with various amounts of the aforementioned polymers were prepared using the wet granulation technique. Tablets prep...

The expense and complications in new drug entities have increased since last 3 decades, with concomitant recognition of the therapeutic advantages of controlled drug delivery. So focus has been given on development of sustained or controlled release drug delivery systems. Bilayer tablet is new novel of tablet for the successful development of controlled release formulation along with various fe...

The purpose of this study was to design and optimize an oral controlled release acyclovir mucoadhesive tablet, in term of its drug release and mucoadhesive strength. A 32 full factorial design was employed to study the effect of independent variables like Carbopol-934P and hydroxypropyl methylcellulose K100M, which significantly influence characteristics like swelling index, ex-vivo mucoadhesiv...

      Mucoadhesive polymers that bind to the gastric mucin or epithelial cell surface are useful in drug delivery for the purpose of increasing the intimacy and duration of contact of drug with the absorbing membrane. Several synthetic polymers are in use for this purpose. Since the biodegradability of the synthetic polymers are questionable, in this investigation, an oral mucoadhesive controll...

The objective of the study was to develop HPMC matrix tablets for oral controlled/ sustained release of water soluble Diclofenac Potassium. Sustained release matrix tablets containing 100 mg of Diclofenac Potassium were developed using different drug polymer ratio of HPMC. Tablets were prepared by direct compression. Compressed tablets were evaluated for uniformity of weight, content of active ...