Although it is fairly common in the Western countries, Paget's disease of bone is very rare in Chinese individuals. Through an extensive literature search, only 8 Chinese Paget's disease cases were found in the English language literature and all were reported in local medical journals of Asia that may not be accessible to international readers. To enhance the awareness of the rarity of Paget's...

This case describes new onset mammary Paget disease arising in the background of Darier disease. Clinically and histologically, lesions of Darier disease can mask the lesions of mammary Paget disease. A high index of suspicion is necessary to diagnose Paget disease in a patient with Darier disease, for a potentially fatal disease could easily be missed.

Received October 2008 Accepted February 2009 INTRODUCTION Extramammary Paget’s disease is a condition morphologically similar to Paget’s disease in the breast, but occurs outside the breast. It is an uncommon condition as compared to its mammary counterpart. It most commonly affects the vulva, less commonly the male genital area or the perianal area.(1,2) To the best of our knowledge, extramamm...

Paget’s disease of bone is a common metabolic disorder, which is in most cases diagnosed on the basis of its radiographic findings. Its primary bone alterations and subsequent complications constitute a complex range of pathologic pictures, which may pose diagnostic difficulties upon histologic examination. This article illustrates the spectrum of pathologic features of Paget’s disease of bone ...

Although many histochemical investigations have been reported on the mucin in the cytoplasm of PAGET cells (LENNOX and PEARSE 1954, STRAUSS 1957, JOHNSON and HELWIG 1963, SASAI, AKIBA and TANAHASHI 1964), there are but few reports concerning an enzymohistochemistry in those cells (BRAUNFALCO and RATHJENS 1955, FANGER and BARKER 1959, STEIGLEDER and KAMEI 1963). In general, it is accepted that t...

A most unusual family with aggressive Paget's disease is reported. Three brothers out of 10 siblings developed the disease at a relatively early age. Two of these brothers developed an osteosarcoma and died. It is emphasized that very little information is available concerning the predisposition to severe polyostotic disease and even sarcomatous change when Paget's disease begins at a young age...

A 32 year old man presented on two separate occasions with severe hypercalcaemia. Both episodes followed the fracture of a single pagetic bone but were not associated with immobilization. To our knowledge this patient, the youngest described with hypercalcaemia secondary to Paget's disease of bone is also the only reported case of recurrent hypercalcaemia in this condition.