Aluminum matrix composites reinforced with Al2O3 and SiC particles (5 Vol%) were produced using the hot powder extrusion method. Extrusion temperature and extrusion reduction in area were chosen in the range of 500 to 600°C and 90 to 95%, respectively. The physical and mechanical properties of the extruded composites such as density, tensile strength, elongation and microhardness were evaluated...

The hydrostatic extrusion is a new method of extrusion process. The most important advantage of this method is reduction of friction and close tolerance for the coating thickness. In this study, the hydrostatic extrusion simulation of bimetallic wires has performed using of finite element method. In the following the advantages of hydrostatic extrusion compared to the direct extrusion are prese...

conclusions it was shown that combination of pectin and eudragits can relatively control drug release in the upper gi. on the other hand, pectin degraded in the presence of pectinase and formulations were susceptible to the colonic media. results it was shown that in the presence of pectin, formulations without erl had a relative resistance to drug release in sgf. pellets containing pectin and ...

In order to develop a kind of APAP double-release pellet capsules, which was prepared with the manual filling method, immediate and sustained release pellets certain proportion were by fluidized bed coating extrusion spheroidization process, respectively. It founded that both immediate-release sustained-release had smooth round surfaces. The particle size distribution ranged evenly from 16 35 m...

In this study, Damar Batu (DB) − a novel biomaterial− is evaluated for its potential application in pharmaceutical coating. DB is a whitish to yellowish resin, characterized initially in terms of solubility, acid value, molecular weight (Mw), polydispersity index (Mw/Mn) and glass transition temperature (Tg). Neat plasticized films of DB are investigated for mechanical, water vapor transmission...

portant component of the mitochondrial respiratory chain (1). Because of its poor aqueous solubility, Coenzyme Q10 (CoQ10) presents a challenge when developing a formulation for oral administration. Many approaches have been used to improve the in vitro dissolution of CoQ10. Some of the approaches include complexation with cyclodextrins (2), preparation of redispersible dry emulsion (3), solid ...

Hot-melt extrusion is one of the most widely applied processing technologies in the plastic, rubber and food industry. Today this technology has found its place in the array of pharmaceutical manufacturing operations. Melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, supp...

the most frequent adverse effects of indomethacin like other nsaids are gastro–intestinal and central nervous system disturbances. extended release or enteric release formulations minimize these symptoms. the objective of this study was to develop an extended release pellet formulation of indomethacin by the centrifugation (rotary fluid bed granulation) or powder layering method. layered, nonpa...

this study was conducted to evaluate the effects of feeding mash versus pellet with different thermal process on blood metabolites, carcass characteristics and broiler performance. 192 (one-day) cobb broiler chicks were used in a completely randomized design with 4 experimental groups (diets) and 4 replicates of ten chicks each (totally 16 pens). the experimental treatment groups consisted of m...