Rock abrasiveness is ability of rock to wear down the working tool during the mutual interaction between the working indentor and the rock in the mechanical rock cutting process. The cutting indentor is worn down during the interaction, which changes its geometric dimensions causing the enlargement of a contact area between the tool and the rock surface. The changes in these dimensions conseque...

In this paper we present a stereo feature-based method using SIFT (Scale-invariant feature transform) descriptors. We use automatic feature extractors, matching algorithms between images and techniques of robust estimation to produce a DTM (Digital Terrain Model) using convergent shots of a rock glacier.The geomorphologic structure observed in this study is the Veleta rock glacier (Sierra Nevad...

Malignant astrocytomas are highly invasive neoplasms infiltrating diffusely into regions of normal brain. Whereas the molecular and cellular mechanisms governing astrocytoma invasion remain poorly understood, evidence in other cell systems has implicated a role for the Rho-GTPases in cell motility and invasion. Here, we examine how the inhibition or activation of Rho-kinase (ROCK) affects astro...

Progression of tumors to invasive and metastatic forms requires that tumor cells undergo dramatic morphologic changes, a process regulated by Rho GTPases. Elevated expression of RhoA and RhoC, as well as the Rho effector proteins ROCK I and ROCK II, are commonly observed in human cancers and are often associated with more invasive and metastatic phenotypes. To examine how ROCK contributes to th...

by Hoek et al. 2002 and which is related to blasting, caused damage and stress relief; it may also be considered in the estimate of rock mass modulus from intact rock modulus. The recommendations of “D” values for tunnel and slope applications were provided by Hoek et al. 2002 . Unfortunately, no guidelines were provided for deep foundation application. The discussers related the disturbance fa...

Rho kinase (ROCK) is a well-known downstream effector of Rho and plays an important role in various physiopathological processes. In this study, we aim to investigate the correlation between ROCK and microvascular damage in rat brain subjected to middle cerebral artery occlusion (MCAO) and reperfusion, and to elucidate the mechanisms underlying the microvascular damage. ROCK and matrix metallop...

Using a proteomic approach, we searched for protein changes dependent on Rho-associated kinase (ROCK) during phorbol-12-myristate-13-acetate (PMA)-induced apoptosis. We found that heterogeneous nuclear ribonucleoprotein C1 and C2 (hnRNP C1/C2), two nuclear restricted pre-mRNA binding proteins, are translocated to the cytosolic compartment in a ROCK-dependent manner in PMA-induced pro-apoptotic ...

The low molecular weight GTPase Rho mediates a variety of cytoskeleton-dependent cell functions and stretch- and G(q) protein-induced hypertrophic responses in cardiac myocytes. Although ROCK, one of Rho's effectors, has been suggested to mediate hypertrophic signals, the relationship of Rho/ROCK with downstream signals is unknown. A zinc finger transcription factor, GATA-4, is activated by ext...

BACKGROUND Rho and its effector Rho-kinase/ROCK mediate cytoskeletal reorganization as well as smooth muscle contraction. Recent studies indicate that Rho and ROCK are critically involved in vascular remodeling. Here, we tested the hypothesis that Rho/ROCK are critically involved in angiotensin II (Ang II)-induced migration of vascular smooth muscle cells (VSMCs) by mediating a specific signal ...

Abstract. Estimations of the reproducibility U–Pb ages from SHRIMP (Sensitive High-Resolution Ion MicroProbe) instruments are based on data studies that nearly 2 decades old. Since time, refinement analytical procedures and operational improvements have reduced historically identified uncertainties analysis. This paper investigates 36 thermal ionisation mass spectrometry (TIMS) double-dated “re...