The mammalian protein siderocalin binds hydroxypyridinone complexes of trivalent rare-earth metals and f-elements through cation-π electrostatic interactions. It can also be fused with biological vectors for the targeted delivery imaging therapeutic radionuclides.

Membrane fusion by the parainfluenza viruses is induced by virus-specific functional interaction between the attachment protein (HN) and the fusion (F) protein. This interaction is thought to be mediated by transient contacts between particular amino acids in the HN stalk domain and those in the F head domain. However, we recently reported that replacement of specified amino acids at or around ...

The effects of Newcastle disease virus (NDV) fusion (F) glycoprotein cleavage mutants on the cleavage and syncytium-forming activity of the wild-type F protein were examined. F protein cleavage mutants were made by altering amino acids in the furin recognition region (amino acids 112 to 116) in the F protein of a virulent strain of NDV. Four mutants were made: Q114P replaced the glutamine resid...

Proteolytic cleavage of the Hendra virus fusion (F) protein results in the formation of disulfide-linked F1 and F2 subunits, with cleavage occurring after residue K109 in the sequence GDVK/L. This unusual cleavage site and efficient propagation of Hendra virus in a furin-deficient cell line indicate that the Hendra F protein is not cleaved by furin, the protease responsible for proteolytic acti...

Defining protein complexes by analysing the protein–protein interaction (PPI) networks is a crucial task in understanding principles of biological cell. In last few decades, researchers have proposed numerous methods to explore topological structure PPI network detect dense complexes. this paper, overlapping with different densities are predicted within an acceptable execution time using seed e...

In this study we hypothesized that the lameness of early lactation dairy cows would have an impact on inline biomarkers, such as rumination time (RT), milk fat (%), protein fat/protein ratio (F/P), lactose (L, %), electrical conductivity all udder quarters, body weight (BW), temperature reticulorumen content (TRR), pH (pH), and walking activity (activity). All 30 lame (LCs) used in experiment h...

For most paramyxoviruses, virus type-specific interaction between fusion (F) protein and attachment protein (hemagglutinin-neuraminidase [HN], hemagglutinin [H], or glycoprotein [G]) is a prerequisite for mediating virus-cell fusion and cell-cell fusion. Our previous cell-cell fusion assay using the chimeric F proteins of human parainfluenza virus 2 (HPIV2) and simian virus 41 (SV41) suggested ...

mechanisms of tolerance to water deficiency stress for introducing sunflower hybrid was investigated by a two-factor experiment as a split plot design based on rcbd was at the research station in alborz province, hashtgerd region, iran in 2013. irrigation rates (irrigation after 50, 100 and 150 mm cumulative evaporation from class a evaporation pan) were considered in the main plots and sunflow...