BACKGROUND Trans-ferulic (FA) acid exhibits antioxidant effects in vitro. However, the underlying mechanism of trans-FA activity in cellular physiology, especially cancer physiology, remains largely unknown. This study investigated the cellular physiological effects of trans-FA on the H1299 human lung cancer cell line. METHODS The 2,2-diphenyl-1-picrylhydrazyl assay was used to determine free...

Introduction: A fatty acid (FA) is a carboxylic acid with a long aliphatic chain, which is either saturated or unsaturated. Recently, the role of FA and particularly omega-3 and -6 has emerged as cardiovascular risk factor in the literature. The aim of our study was to establish reference values for these FA and to compare them with data obtained in a population of acute myocardial infarction (...

Fusidic acid (FA) is derived from the fungus Fusidiumcoccineum which was originally isolated from monkey faeces and available in the market since 1962. FA inhibits bacterial protein synthesis by interference with elongation factor G (EF-G), which promotes translocation on the ribosome after peptide bond formation, preventing further elongation by inhibiting the GTPase function of the EF-G. The ...

Fluctuating asymmetry (FA) is defined as random deviations from bilateral symmetry of the body. Thus, its magnitude is often used to evaluate developmental homeostasis. In this study we evaluate the following hypotheses: 1) FA of dermatoglyphic traits has a significant genetic component; 2) prenatal maternal environment (PME) has a significant effect on the FA of dermatoglyphic traits in develo...

PURPOSE In vivo imaging of GABAA receptors is essential for the comprehension of psychiatric disorders in which the GABAergic system is implicated. Small animal SPECT provides a modality for in vivo imaging of the GABAergic system in rodents using [(123)I]Iomazenil, an antagonist of the GABAA receptor. The goal of this work is to describe and evaluate different quantitative reference tissue met...

Famously, scientific theories are underdetermined by their evidence. This occurs in the factor analytic model (FA), which is often used to connect concrete data (e.g. test scores) to hypothetical notions (e.g. intelligence). After introducing FA, three general topics are addressed. (i) Underdetermination: the precise reasons why FA is underdetermined illuminates various claims about underdeterm...

BACKGROUND Food allergy (FA) is a growing condition among children and it's psychological impact over the patients and their caregivers is well known, establishing a vicious circle that perpetuates stress levels. However, psychosocial factors are not commonly included in allergy treatments. Based on the lack of evidence of records about a scale that indicates the level of interaction between bi...

It is becoming a consensus that white matter integrity is compromised in schizophrenia (SZ), however the underlying genetics remains elusive. Evidence suggests a polygenic basis of the disorder, which involves various genetic variants with modest individual effect sizes. In this work, we used a multivariate approach, parallel independent component analysis (P-ICA), to explore the genetic underp...

All molybdoenzyme activities are absent in chlB mutants because of their inability to synthesize molybdopterin guanine dinucleotide, which together with molybdate constitutes the molybdenum cofactor in Escherichia coli. The chlB mutants are able to synthesize molybdopterin. We have previously shown that the inactive nitrate reductase present in a chlB mutant can be activated in a process requir...

In this study, the application of factor analytic (FA) rotation methods in the context of neuroimaging data analysis was explored. Three FA algorithms (ProMax, QuartiMax, and VariMax) were employed to carry out blind source separation in a functional magnetic resonance imaging (fMRI) experiment that involved a basic audiovisual stimulus paradigm. The outcomes were compared with those from three...