The aim of the present study was to investigate the effects of stearic acid-, oleic acid- and linoleic acid-rich meals on postprandial haemostasis in young healthy volunteers whose background diets had been controlled for 14 d in a residential study. Six healthy male volunteers were assigned randomly to consume diets rich in stearic acid, oleic acid or linoleic acid for 14 d. On day 15, plasma ...

Recent reports have suggested that thromboplastin (Tpl) prepared from lung may reflect more accurately than does brain Tpl the changes produced in the prothrombin complex by coumarin derivatives (1, 2). As evidence for this, it has been observed that as factor VII concentration decreases in the plasma of Dicumarol '-treated patients, the prothrombin time obtained with lung Tpl becomes dispropor...

All reported adsorbents of prothrombin simultaneously adsorb proconvertin, and practically all described techniques of elution have resulted in their simultaneous release from these adsorbents. In this paper we present information about a material selectively removing prothrombin from an eluate containing prothrombin, proconvertin, and hemophilia B factor (PTC, Christmas factor). The substance ...

It has long been known that the " prothrombin " time of a specimen of plasma to which has been added a brain extract thromboplastin depends on the presence of other factors in addition to prothrombin. Biggs, Douglas, and Macfarlane (1953) have demonstrated that both factor V and factor VII take part in a preliminary reaction with the brain extract to produce an activated thromboplastin. Hardist...

Factor VII (FVII) is found in small amounts in plasma and has a very short half-life in circulation. FVII is vitamin K-dependently synthesized in the liver. As such, hepatopathies, vitamin K deficiency, or use of vitamin K antagonists is the cause of acquired deficiency. Other types of acquired FVII deficiencies are rare.1 Here we describe a case of acquired factor VII deficiency associated to ...

A rare case of multiple cerebral aneurysms and factor VII deficiency is presented. The authors hypothesize a possible combined genetic defect similar to that of other conditions with clotting disorders. Different treatment options are discussed for factor VII deficiency in particular and multiple cerebral aneurysms in general. The authors advise treatment of all detected aneurysms in case of a ...

We have extended earlier studies (Blood 66:204, 1985) of a mechanism of inhibition of factor VIIa/tissue factor activity that requires a plasma component (called herein extrinsic pathway inhibitor or EPI) and factor Xa. An activated peptide release assay using 3H-factor IX as a substrate was used to evaluate inhibition. Increasing the tissue factor concentration from 20% to 40% (vol/vol) overca...