Ethanol exposure during development causes an array of developmental abnormalities, both physiological and behavioral. In mammals, these abnormalities are collectively known as fetal alcohol effects (FAE) or fetal alcohol spectrum disorder (FASD). We have established a Drosophila melanogaster model of FASD and have previously shown that developmental ethanol exposure in flies leads to reduced e...

This paper presents a new approach to exploit data-driven universal background model (UBM) generation using tied Gaussians for accent identification (AID). The motivation of the proposed algorithm is to potentially utilize broad phoneticspecific accent characteristics by Gaussian mixture model (GMM) and examine data-driven phonetically-inspired UBM creation for GMM-supervector based accent clas...

M cells represent a potential portal for oral delivery of peptides and proteins due to their high endocytosis abilities. An in vitro model of human FAE (co-cultures) was used to evaluate the influence of M cells on the transport of free and encapsulated helodermin--a model peptide--across the intestinal epithelium. M cells enhanced transport of intact helodermin (18-fold, Papp=3 x 10(-6) cm s(-...

In this article, we are focusing on metaphor of mental states examining hidden dimension of the human mind and its interaction with a world. Our natural language research methodology were included constructing a database of metaphorical stimuli, randomly presenting these to participants, and tabulating FAE responses both by participant and by the stimulus, analyzed by frequency of semantic type...

We have shown previously that liquid extraction surface analysis of dried blood spots coupled to high resolution top-down MS may be applied for the diagnosis of hemoglobin (Hb) variants FS, FAS, FC, FAC, FAD in newborn samples. The objective of the current work was to determine whether the structural variant HbE, compound heterozygote variants FSC and FSD, and β-thalassemia were amenable to dia...