cronkhite-canada syndrome (ccs) is a rare, non-familial disorder of unknown etiology associated with alopecia, cutaneous hyperpigmentation, gastrointestinal polyposis, onychodystrophy, diarrhea, weight loss and abdominal pain.the prevalence ofâ gastrointestinal malignancy in ccs patients is about 13%, and especially is high in colorectal and gastric areas; 5 year mortality rate is 55%. in this ...

introduction: the objective of the present study is to investigate the relationship between the familial history of digestive system cancers and development of gastric cancer. methods: in this case-control study conducted in 2012, 84 patients with a definite diagnosis of gastric cancer, diagnosed using endoscopy and pathological study of biopsies, were compared with 84 people with the same age ...

background hepatitis c virus (hcv) is a major cause of chronic liver disease worldwide. the role of intra familial hcv transmission is still controversial. the aim of the present study is to determine intra familial transmission (sexual and non sexual contacts) of hcv in a group of iranian population. patients and methods in this historical cohort study, 270 first degree relatives of hepatitis ...

background since genetic and most environmental factors shape the context of families, some studies have been initiated to investigate the role of familial relationships in metabolic syndrome (mets). objectives to estimate the familial aggregation of mets and its components by identifying both case and control probands among tehranian adults with different socio-behavioral and reproductive char...

introduction dilated cardiomyopathy (dcm) is the leading cause of heart failure and arrhythmia. case presentation a 47-year-old male, diagnosed with dilated cardiomyopathy, died due to heart failure. during the screening of his family members, his 17-year-old daughter and 9-year-old son also had dilated cardiomyopathy. another daughter had died suddenly at the age of 12 years. conclusions we he...

Two boys with bilateral agenesis of kidneys and ureters were the product of a consanguineous marriage. This family and previous reports of familial bilateral renal agenesis support the supposition that a minor proportion of cases of BRA is caused by the homozygous state of an autosomal recessive gene.

BACKGROUND AND PURPOSE It is uncertain whether familial occurrence of brain arteriovenous malformations (BAVMs) represents coincidental aggregation or a shared familial risk factor. We aimed to compare the prevalence of BAVMs in first-degree relatives (FDRs) of patients with BAVM and the prevalence in the general population. METHODS We sent a postal questionnaire to 682 patients diagnosed wit...

Neurological assessment was carried out on patients with schizophrenia from multiply and singly affected families, their relatives, and a normal control group (214 subjects). A systematic examination was used in which abnormal signs were divided into 'primary' and 'integrative' signs. Primary signs were elicited by a standard clinical neurological examination and included signs of focal damage ...

While the literature cites a number of examples for why STEM teachers leave high-need school (HNS) contexts, there are fewer studies that address stay. Through examination teacher participants who accepted scholarship to teach in HNSs, we sought understand aspects their identities and social experiences supported commitment. Using qualitative methodology thematic analysis, found enact researche...