Methylmercury (MeHg) is a ubiquitous contaminant largely found in aquatic environments, especially species at high trophic level such as salmonids. The aim of this study was to evaluate the effects MeHg on adipocyte differentiation and lipid metabolism rainbow trout. Primary cultured preadipocytes were exposed increasing concentrations during six days with or without hormonal cocktail. Main res...

Here, we demonstrate detection by mass spectrometry of an intact protein–drug complex directly from liver tissue rats that had been orally dosed with the drug. The comprised fatty acid binding protein 1, FABP1, non-covalently bound to small molecule therapeutic bezafibrate. Moreover, spatial mapping [FABP1+bezafibrate] across a thin section targeted imaging. This work is first demonstration in ...