OBJECTIVE To compare bleeding profiles and satisfaction among women using a norelgestromin/ethinyl estradiol (E2) transdermal contraceptive patch in an extended regimen to those among women using a traditional 28-day patch regimen. METHODS Healthy, regularly menstruating women (N = 239) were randomly assigned (2:1 ratio) to receive the norelgestromin/ethinyl E2 transdermal patch in an extende...

Metal patch test is often used in clinical settings when metal-induced contact dermatitis is suspected. However, the transdermal permeation behavior of metal ions from the patch test remains unclear. Current patch tests using high concentrations of metal salt solutions have some side effects, e.g. acute skin reactions to high concentrations of metal salt. To resolve these, estimating metal ion ...

This case report involving a placebo-controlled nicotine patch trial illustrates the difficult issue of conducting placebo studies in pregnancy, when one of the two patients involved cannot be asked to consent.

241 A Perioperative Pain Management Strategy for Elective Cesarean Section in a Patient on Chronic Buprenorphine/Naloxone Therapy Abstract Type: Case Report/Case Series Matthew D. Cohen, D.O.; Marte A. Martinez, M.D. The University of Oklahoma Health Sciences CenterType: Case Report/Case Series Matthew D. Cohen, D.O.; Marte A. Martinez, M.D. The University of Oklahoma Health Sciences Center Obj...

Topical analgesics can play an important role in the therapeutic armamentarium for pain management. The mechanism of action of topical analgesics is largely within the peripheral nervous system. However, recent clinical investigations suggest that the effect of topical analgesics on peripheral processing of pain transmission may lead to the dampening of central pain mechanisms as well. Thus, in...

The body of scientific literature on transdermal alcohol testing dates back almost 70 years. The first viable method enabling this knowledge appeared in the 1980s in the form of an alcohol “sweat-patch”. Recently, transdermal alcohol monitoring bracelets have been used to measure transdermal vapor alcohol. Based on published research in this field, one can conclude that measuring alcohol transd...

Forty-eight patients with noncancer neuropathic pain who had participated in a randomized controlled trial with intravenous fentanyl (FENiv) infusions received prolonged transdermal fentanyl (FENtd) in an open prospective study. Pain relief, side effects, tolerance, psychological dependence, mood changes, and quality of life were evaluated. The value of clinical baseline characteristics and the...