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تعداد نتایج: 169 فیلتر نتایج به سال:
In the present thesis, the aim was to probe the distribution and functions of galanin type 2 receptor (GalR2) in the rodent brain. In order to overcome the lack of a reliable antibody to localize GalR2 by immunohistochemistry, we generated a construct which expresses GalR2 tagged with enhanced GFP (EGFP). We first studied the trafficking and function of this fusion protein in cell lines, includ...
Evidence suggests that the long-term adaptations in the hippocampus after repeated drug treatment may parallel its role during memory formation. The neuroplasticity that subserves learning and memory is also believed to underlie addictive processes. We have reported previously that repeated morphine administration alters local distribution of endocytic proteins at hippocampal synapses, which co...
In the present study, we describe the characterization of a positive allosteric modulator at metabotropic glutamate subtype 2 receptors (mGluR2). N-(4-(2-Methoxyphenoxy)-phenylN-(2,2,2-trifluoroethylsulfonyl)-pyrid-3-ylmethylamine (LY487379) is a selective positive allosteric modulator at human mGluR2 and is without activity at human mGluR3. Furthermore, LY487379 has no intrinsic agonist or ant...
Glucocorticoid and mineralocorticoid receptor signals are important for memory formation, salt cravings, sympathetic tone and hypothalamic–pituitary–adrenal (HPA) axis control in the brain. Exacerbations of glucocorticoid and mineralocorticoid receptor signaling cause atherosclerosis, cognitive dysfunction, and depression. Mineralocorticoid activity is modulated by oxidative stress, and chronic...
3-tert-Butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4triazol-5-ylmethoxy)-pyrazolo[1,5-d][1,2,4]triazine (MRK-016) is a pyrazolotriazine with an affinity of between 0.8 and 1.5 nM for the benzodiazepine binding site of native rat brain and recombinant human 1-, 2-, 3-, and 5-containing GABAA receptors. It has inverse agonist efficacy selective for the 5 subtype, and this 5 inverse agonism...
5IA is a compound that binds with equivalent subnanomolar affinity to the benzodiazepine (BZ) site of GABAA receptors containing an 1, 2, 3, or 5 subunit but has inverse agonist efficacy selective for the 5 subtype. As a consequence, the in vitro and in vivo effects of this compound are mediated primarily via GABAA receptors containing an 5 subunit. In a mouse hippocampal slice model, 5IA signi...
Change in the synaptic communication between neurons—known as synaptic plasticity—plays a key role in learning and memory. It is not yet clear, however, whether the properties of synaptic plasticity are sufficient to account for long-term-memory maintenance. Recent studies have revealed that synaptic plasticity can indeed persist for weeks or months, as might be expected of a longterm-memory me...
•Transgenic overexpression of Ndr2 in neurons impairs hippocampus-dependent behavior•Ndr2 gene amplification disturbs mossy fiber plasticity and CA3-CA1 network activity•Transgenic attenuates granule cell maturation growth•Interactome analysis identifies Ndr2-related intracellular signaling pathways Duplications deletions short chromosomal fragments are increasingly recognized as the cause for ...
Olfactory bulbectomy (OBX) in mice elicits impaired memory and cognitive functions. Here, we found that chronic oral administration of spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)one (ZSET1446/ST101) (0.1–1 mg/kg/day), a novel cognitive enhancer, significantly improved memory deficits as assessed by Y-maze and novel object recognition tasks in OBX mice. Immunostaining of cholinergic neurons in...
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