Thyroid hormone is essential for mammalian brain development, but the mechanisms by which thyroid hormone exerts its effects, the developmental processes affected, and the timing of thyroid hormone effects are poorly understood. An important question is whether thyroid hormone of maternal origin is essential in guiding fetal brain development. In both humans and rats, thyroid hormone of materna...

background: infection with parvovirus b19 may cause fetal losses including spontaneous abortion, intrauterine fetal death and non-immune hydropsfetalis. the aim of this study is to determine the frequency of parvovirus b19 in formalin fixed placental tissues in lost fetuses using real-time pcr method.   methods : in this cross-sectional study, 100 formalin fixed placental tissues with unknown c...

Introduction Fetal MR brain imaging is proving to be a powerful modality with which to evaluate the developing fetal brain. Advanced imaging strategies, such as diffusion weighted imaging (DWI) and diffusion tensor imaging (DTI) have recently been applied to the human fetus [1,2]. The major difficulty of performing DWI of the fetal brain in utero is the presence of motion, which is especially m...

Endocrine disrupting compounds (EDCs) include organochlorine pesticides (OCPs), organophosphate pesticides (OPPs), carbamate pesticides, and plasticizers, such as bisphenol A (BPA). They persist in the environment because of their degradation resistance and bioaccumulate in the body tissues of humans and other mammals. Many studies are focused on the possible correlation between in utero exposu...

In biomedical engineering, to extract the fetal electrocardiogram (FECG) exactly is a significant and challenging research topic, and so it has been a hot field in biomedical research. Now, a variety of different methods have been proposed to address this problem. From the perspective of blind signal processing, FECG extraction can be modeled as Blind source separation (BSS). In this paper, we ...

The development of tools to construct and investigate probabilistic maps of the adult human brain from magnetic resonance imaging (MRI) has led to advances in both basic neuroscience and clinical diagnosis. These tools are increasingly being applied to brain development in adolescence and childhood, and even to neonatal and premature neonatal imaging. Even earlier in development, parallel advan...

The development and identification of best methods in fetal brain MRI analysis is crucial as we expect an outburst of studies on groupwise and longitudinal analysis of early brain development in the upcoming years. To address this critical need, in this paper, we have developed a mathematical framework for the construction of an unbiased deformable spatiotemporal atlas of the fetal brain MRI an...