AIM Presentation of a prenatally diagnosed case of Werdnig-Hoffmann disease, the most severe type of spinal muscular atrophy. METHODS DNA obtained from cultivated amniocytes was analyzed for deletions in the survival motor neuron gene and neuronal apoptosis inhibitory protein gene. RESULTS The fetus was diagnosed as an affected homozygote for deletions in exon 7 and exon 8 of the survival m...

BACKGROUND AND OBJECTIVES Laparoscopic surgical techniques in pregnancy have been accepted and pose minimal risks to the patient and fetus. We present the first reported case of a pregnant woman with immune thrombocytopenia purpura who underwent laparoscopic splenectomy during the second trimester. METHODS AND RESULTS The anesthesia, hematology, and obstetrics services closely followed the pa...

BACKGROUND Mirror syndrome (MS) is a rare obstetric condition usually defined as the development of maternal edema in association with fetal hydrops. The pathogenesis of MS remains unclear and may be misdiagnosed as pre-eclampsia. CASE PRESENTATION We report a case series of MS in which fetal therapy (intrauterine blood transfusion and pleuroamniotic shunt) resulted in fetal as well as matern...

In fetus, while minor degree of hydrocephalus often goes undetected, severe cases of obstructive variety present with the following features: 1 .the head is felt larger, globular and softer than the normal head 2.the head is high up and difficult to push down into pelvis 3.fetal heart sound is situated high up above the umbilicus 4.internal examination during labor may reveal widening of suture...

Background: Following emergence of Zika virus in the Americas, a devastating new congenital syndrome has been documented, leading to significant morbidity among Zika-infected fetuses and neonates. Case presentation: A 29-year-old pregnant woman infected with Zika virus at 9-weeks gestation in Trinidad presented with one-month of fever, headache, and myalgia with persistent viremia. Significant ...

INTRODUCTION Brain abscess in pregnancy is very rare, which mostly progresses to neurological abnormalities. CASE PRESENTATION The patient is a 24-year-old pregnant woman. She was referred to Saitama hospital due to severe headache and nausea on October 2008. Brain MRI detected a 1.5 cm abscess mass with extensive edema in the right frontal lobe. We performed intensive therapy using some anti...

Neuroblastoma is the most common malignant tumour in the neonatal age group. The tumour is derived from neural crest cells of adrenal gland medulla or sympathetic ganglia. Disseminated congenital neuroblastoma is very rare. We hereby report a case of congenital neuroblastoma with multiple metastases diagnosed on autopsy in a fetus of 23 weeks gestational age. Autopsy revealed enlarged bilateral...

The absence of a cerebellum is extremely rare condition and the clinical presentation is variable. We aimed to present a case with isolated cerebellar agenesis in a pregnant woman at 23 weeks of gestation. Twenty seven years old primigravid patient was referred to our obstetrics outpatient clinic with a suspicion of cerebellar in her fetus. Cerebellum agenesis has been identified by ultrasound ...

The influence of priority factors such as vitamins during the period fetal development in three trimesters is considered. analysis dynamics fetus, taking into account saturation nutrients and food products. main influencing fetus have been investigated, types products that provide a rational diet for pregnant women identified. Developed mathematical model differentiated dietary nutrition prenat...