Fatal familial insomnia (FFI) is a prion disease clinically characterised by progressive insomnia and dysautonomia, and associated with an aspartic acid to asparagine mutation at the codon 178 (D178N) of the prion protein gene (PRNP). This mutation is also associated with familial Creutzfeldt-Jakob disease (CJD). These phenotypes have been held to depend on the polymorphism at the codon 129. FF...

Fatal familial insomnia (FFI) is a prion disease clinically characterised by progressive insomnia and dysautonomia, and associated with an aspartic acid to asparagine mutation at the codon 178 (D178N) of the prion protein gene (PRNP). This mutation is also associated with familial Creutzfeldt-Jakob disease (CJD). These phenotypes have been held to depend on the polymorphism at the codon 129. FF...

Farmland fragmentation has emerged as the primary manifestation of global land use changes during last century. Following economic reform and opening up in China from 1980s, Beijing–Tianjin–Hebei (BTH) region witnessed continuous farmland fragmentation. Understanding spatial–temporal dynamics is crucial for formulating sustainable management strategies. However, specific causes locations remain...

OBJECTIVE To investigate the clinical effectiveness of early foot orthosis intervention for painful correctable valgus deformity of the rearfoot in rheumatoid arthritis (RA). METHODS Patients with RA were randomized to receive custom manufactured rigid foot orthoses under podiatry supervision (n = 50) or enter a control group (n = 48). The control group received foot orthoses only when prescr...

BACKGROUND Osteoarthritis of the first metatarsophalangeal joint (1st MTPJ OA) is a common and disabling condition commonly managed with footwear and orthotic interventions. The objective of this study was to identify factors associated with a successful treatment response in people with 1st MTPJ OA provided with prefabricated orthoses or rocker-sole footwear as part of a randomised clinical tr...

OBJECTIVE To examine whether personality traits are related to all-cause mortality in a general adult population in Scotland. METHODS The Edinburgh Artery Study began in 1987 to 1988 by recruiting 1592 men and women aged 55 to 74 years to be followed-up for atherosclerotic diseases. The NEO Five-Factor Inventory (NEO-FFI) was completed by 1035 surviving participants in 1995 to 1996. Deaths fr...

OBJECTIVE Norepinephrine is an important chemical messenger that is involved in mood and stress in humans, and is reabsorbed by the norepinephrine transporter (NET). According to Cloninger's theory, the noradrenergic system mediates the personality trait of reward dependence. Thus far, although association studies on NET gene polymorphisms and Cloninger's personality traits have been reported, ...

OBJECTIVES Our objectives were to test whether Conscientiousness, the other 4 domains of the Five-Factor Model, and their facets predicted mortality in older, frail individuals. METHODS Controlling for demographic and health measures, we used Cox regression to test whether the NEO Five-Factor Inventory (NEO-FFI) Neuroticism, Extraversion, Openness to Experience, Agreeableness, and Conscientio...

Objective: Plantar fasciitis is one of the primary causes heel pain. Several treatment methods are substantial. This study was aimed to evaluate clinical results corticosteroids and prolotherapy injection therapies.Methods: The gender, age, time symptoms, BMI (body mass index) were specified in 60 patients with symptomatic chronic plantar disorder between 2019 2020. randomly divided into two gr...

Seismic fluid identification plays an important role in reservoir exploration and development. Natural vertical fractures are common carbonate rocks, it is essential to consider fracture-induced anisotropy the of fractured reservoirs. We have developed a novel Bayesian elastic impedance variation with angle azimuth (EIVAZ) inversion approach for directly estimating fracture indicator (FFI), whi...