Fibrin, the coagulation end product, consolidates the platelet plug at sites of vascular injury and supports the recruitment of circulating platelets. In addition to integrin αIIbβ3, another as-yet-unidentified receptor is thought to mediate platelet interaction with fibrin. Platelet glycoprotein VI (GPVI) interacts with collagen and several other adhesive macromolecules. We evaluated the hypot...

Recent data indicate an important contribution of coagulation factor (F)XII to in vivo thrombus formation. Because fibrin structure plays a key role in clot stability and thrombosis, we hypothesized that FXII(a) interacts with fibrin(ogen) and thereby regulates clot structure and function. In plasma and purified system, we observed a dose-dependent increase in fibrin fiber density and decrease ...

PURPOSE To report a specific line of research developed at the University of São Paulo/Brazil on fibrin glue used for sealing corneal perforations and the perspectives of use on non-perforated corneal ulcers and photorefractive keratectomy-operated corneas. METHODS To describe fibrin glue manufacture, development of a device to test the glued perforated corneal area resistance, subsequent exp...

Type 1 plasminogen activator inhibitor (PAI-1), the primary inhibitor of tissue-type plasminogen activator (t-PA), circulates as a complex with the abundant plasma glycoprotein, vitronectin. This interaction stabilizes the inhibitor in its active conformation In this report, the effects of vitronectin on the interactions of PAI-1 with fibrin clots were studied. Confocal microscopic imaging of p...

Thromboembolic disease is a leading cause of morbidity and mortality worldwide. In the last several years there have been a number of studies attempting to identify mechanisms that stop thrombus growth. This paper identifies a novel mechanism related to formation of a fibrin cap. In particular, protein transport through a fibrin network, an important component of a thrombus, was studied by inte...

We survey lower bounds for the variant of the two-dimensional bin packing problem where items cannot be rotated. We prove that the dominance relation claimed by Carlier et al.[5] between their lower bounds and those of Boschetti and Mingozzi [1] is not valid. We analyze the performance of lower bounds from the literature and we provide the results of a computational experiment.

We prove that Best Fit bin packing has linear waste on the discrete distributionU{j, k} (where items are drawn uniformly from the set {1/k, 2/k, · · · , j/k}) for sufficiently large k when j = αk and 0.66 ≤ α < 2/3. Our results extend to continuous skewed distributions, where items are drawn uniformly on [0, a], for 0.66 ≤ a < 2/3. This implies that the expected asymptotic performance ratio of ...

Interaction of tissue plasminogen activator (t-PA) with fibrin plays a key role in regulation of plasminogen activation and clot dissolution. Previous investigations of t-PA-fibrin interaction, using incorporation of t-PA into polymerizing fibrin clots, have suggested that no significant differences exist in the binding of one-chain or two-chain t-PA to non-cross-linked or cross-linked fibrin. ...