Fibromyalgia syndrome (FMS) is a widespread pain condition associated with a wide range of additional symptoms including fatigue, insomnia, depression, anxiety and stiffness. Duloxetine is one of three medications currently FDA approved for use in FMS management. Duloxetine is a mixed serotonin and norepinephrine reuptake inhibitor (SNRI) that functions by increasing central nervous system leve...

Fibromyalgia Syndrome (FMS) is a chronic disease characterized by widespread pain, and difficult to diagnose and treat. We analyzed the plasma metabolic profile of patients with FMS by using a metabolomics approach combining Liquid Chromatography-Quadrupole-Time Of Flight/Mass Spectrometry (LC-Q-TOF/MS) with multivariate statistical analysis, aiming to discriminate patients and controls. LC-Q-T...

Objective: Fibromyalgia syndrome (FMS) is a chronic condition characterized by widespread musculoskeletal pain associated with a variety of other symptoms. In order to evaluate the effects of a multimodal analgesia approach to the treatment of FMS, a retrospective observational study was performed. Methods: Sixty-nine consecutive outpatients, seen for the first time and diagnosed with FMS, were...

BACKGROUND Fibromyalgia (FMS) is a pain condition affecting 2-6% of US adults; effective treatment remains limited. Determinants of nonvitamin, nonmineral dietary supplement (NVNM) use among adults with FMS are not well-studied. We investigated the relation of NVNM use to FMS, and trends, in two nationally representative samples of US adults ≥18 years. METHODS Data were drawn from 2007 and 20...

OBJECTIVE To systematically investigate the scientific evidence relating to electrothermal and phototherapeutic methods for the treatment of fibromyalgia syndrome (FMS). METHODS The search for reports on interventions using electrothermal and phototherapy for FMS was carried out in the Pubmed, Medline, Lilacs, Scielo, ISI Web of Knowledge, PEDro and Cochrane Collaboration databases. Randomize...

Fibromyalgia syndrome (FMS) is characterized by widespread chronic pain and tenderness. Persons with FMS are a diverse population, with widely variable symptom presentation and severity, as well as secondary symptoms. Because the symptoms are so diverse, diagnosis and management become challenging. Mounting evidence supports altered CNS processing of nociceptive stimuli as a mechanism. American...

The objective of this study was to analyze the perception visual verticality (VV) in subjects with Fibromyalgia Syndrome (FMS) and correlate symptoms disease balance capacity. A cross-sectional including 54 patients (51 female) conducted. evaluation carried out a virtual reality device by calculating Mean Absolute Error (MAE) degrees deviation two tests: Subjective Visual Vertical (SVV) test fo...

Fibromyalgia syndromes (FMS) is a chronic and debilitating musculoskeletal pain disorder of unknown aetiology with usual accompanying features of fatigue, sleep disturbances and stiffness and is one of the least understood pain syndrome in medicine today. Other symptoms include tingling of the skin, prolonged muscle spasms, weakness in the limbs, nerve pain, muscle twitching and chronic sleep d...

Data from an open-label trial suggest that mirtazapine might prove useful in treatment of fibromyalgia syndrome (FMS). To obtain preliminary efficacy data of mirtazapine for estimation of sample size requirements for a Phase 2 clinical trial in FMS. This 13-week randomized controlled trial compared the effects of mirtazapine 15 mg/day, mirtazapine 30 mg/day, and placebo in 40 patients with FMS....