Introduction. 5a-reductase inhibitors (5a-RIs), finasteride and dutasteride, have been approved for treatment of lower urinary tract symptoms, due to benign prostatic hyperplasia, with marked clinical efficacy. Finasteride is also approved for treatment of hair loss (androgenetic alopecia). Although the adverse side effects of these agents are thought to be minimal, the magnitude of adverse eff...

Ovarian steroids such as estrogen and progesterone have been reported to influence knee laxity. The effect of testosterone, however, remains unknown. This study investigated the effect of testosterone on the knee range of motion (ROM) and the molecular mechanisms that might involve changes in the expression of relaxin receptor isoforms, Rxfp1 and Rxfp2 in the patella tendon and lateral collater...

The findings from the Prostate Cancer Prevention Trial (PCPT) and how they relate to the management of prostate disease were reviewed by leading European urologists during a meeting held in December 2005. The consensus opinions that were reached were endorsed by the European Association of Urology and are documented here. The key points of the consensus are as follows: (1) The overall results f...

Prostate cancer is the most common non-skin cancer in the United States, the second leading cause of death from cancer among U.S. men, and the seventh leading cause of death in the United States. The number of new cases of prostate cancer, now estimated at more than 220,000 per year, is expected to increase to more than 380,000 by 2025 because of the aging male population. The incidence of pros...

Treatment of benign prostatic hyperplasia (BPH) has evolved over that last 10 years consequent to the results of several important clinical trials. Although the primary concern for patients is their symptoms, we as urologists are further concerned about the progression of disease and complications of the disease. Two classes of medications, alpha blockers and 5 alpha reductase inhibitors (5ARI)...

A few years ago, I attended the annual meeting of the Clinical Ligand Assay Society. From the airport, I took a taxi to my hotel. The taxi driver, a 60-year-old man, was curious and asked why I was visiting Philadelphia. I told him that I was attending a medical conference and giving a lecture on prostate cancer. He immediately got very excited! He showed me a 2-L Coca Cola bottle, which was ha...

CONTEXT Androgenetic alopecia is the most common form of alopecia in men. OBJECTIVE To determine the efficacy and safety of finasteride therapy for patients with androgenetic alopecia. DATA SOURCES MEDLINE, EMBASE, CINAHL, Cochrane Registers, and LILACS were searched for randomized controlled trials reported in any language that evaluated the efficacy and safety of finasteride therapy in co...

Reassessment of the reported single-crystal X-ray diffraction characterization of polymorphs of furosemide and finasteride shows that, in each case, incomplete data collections have resulted in the mistaken identification of two forms that are, in fact, identical.

INTRODUCTION Long-term adverse symptoms of men who used oral finasteride against androgenic alopecia have been recently described as post-finasteride syndrome (PFS). AIM To determine whether (CAG)n-rs4045402 and (GGN)n-rs3138869 polymorphisms in the androgen receptor (AR) gene are implicated in PFS. METHODS AR polymorphisms were studied according to PFS symptoms in 66 white participants (31...