نتایج جستجو برای: flavopiridol
تعداد نتایج: 461 فیلتر نتایج به سال:
Background: The positive transcription elongation factor, P-TEFb, comprised of cyclin dependent kinase 9 (Cdk9) and cyclin T1, T2 or K regulates the productive elongation phase of RNA polymerase II (Pol II) dependent transcription of cellular and integrated viral genes. P-TEFb containing cyclin T1 is recruited to the HIV long terminal repeat (LTR) by binding to HIV Tat which in turn binds to th...
In Escherichia coli, sn-glycerol-3-phosphate can be oxidized by two different flavo-dehydrogenases, an anaerobic enzyme encoded by the glpACB operon and an aerobic enzyme encoded by the glpD operon. These two operons belong to the glp regulon specifying the utilization of glycerol, sn-glycerol-3-phosphate, and glycerophosphodiesters. In glpR mutant cells grown under conditions of low catabolite...
Dioxygen activation at copper(i) centres is of primary importance for the development of sustainable oxidation catalysis, but regeneration of copper(i) centres after each catalytic cycle remains a major problem for multi-turn-over catalysis. This work demonstrates that an artificial reductase, made of flavin cofactors incorporated into a water soluble polymer, efficiently reduces a Cu(ii)TPA co...
Drugs. The Drug Synthesis and Chemistry Branch, Division of Cancer Treatment, NCI, National Institutes of Health (NIH), provided camptothecin (CPT) and flavopiridol (FLV). Aphidicolin (APD), 5,6-dichlorobenzimidazole 1-β-D-ribofuranoside (DRB), and α-amanitin were obtained from Sigma (St Louis, MO). Hydrogen peroxide (H2O2) was obtained from Fisher Scientific (Pittsburgh, PA). Iodouridine (IdU)...
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