An oral sustained-release floating tablet formulation of metformin HCl was designed and developed. Effervescence and swelling properties were attributed on the developed tablets by sodium bicarbonate and HPMC-PEO polymer combination, respectively. Tablet composition was optimized by response surface methodology (RSM). Seventeen (17) trial formulations were analyzed according to Box-Behnken desi...

The main objective of the present study was to formulate gastroretentive effervescent sustained release drug delivery systems of risperidone floating tablets with the help of Methocel® K15, Ethocel® standard 7FP premium, Eudragit ® RS100 sustained release polymers to improve its safety profile, bioavailability and patient compliance. Risperidone floating tablets were formulated by wet granulati...

Floating medicines work well to increase drug absorption in the stomach. On basis of current literature, a for novel delivery system (NDDS) is established explicate floating (FDDS). The most recent FDDS progress involves formulation as physiological aspects that may affect gastric retention and formulation. This review also discusses certain ways producing system, evaluation methods, characteri...

With the aim of extending the use of integrated variational principles on fluid and deckplate to the large deflection analysis of floating roofs, this paper investigates the significance of theflexural and membrane components in the formulations of the deck plate. Applying integratedvariational principles on deck plate and fluid facilitate the treatment of the compatibility ofdeformation betwee...

Many small countries are in real need of additional sovereign territory. Sometimes, they even build on rotting landfills and install various kinds of expensive artificial islands. The ocean covers 71% of our Earth’s surface. Those countries (or persons of wealth) starting the early colonization of the ocean may obtain advantages through additional territory or creating their own independent sta...