Intensity modulated radiation therapy (IMRT) and three-dimensional conformal radiation therapy (3D CRT) are two treatment modalities in prostate cancer, which provide acceptable dose distribution in tumor region with sparing the surrounding normal tissues. IMRT is based on inverse planning optimization; in which, intensity of beams is modified by using multileaf collimators and also compensator...

Purpose: We use reduced-order constrained optimization (ROCO) to create clinically acceptable IMRT plans quickly and automatically for advanced lung cancer patients. Our new ROCO implementation works with the treatment planning system and full dose calculation used at Memorial Sloan-Kettering Cancer Center, and we have implemented mean dose hard-constraints, along with the point-dose and dose-v...

Submit Manuscript | http://medcraveonline.com Abbreviations: TCP: Tumor Control Probability; NTCP: Normal Tissue Control Probability; LKB: Lyman Kutcher Burman; IGRT: Image Guided Radiation Therapy; IMRT: Intensity Modulated Radiation Therapy; SIB-IMRT: Simultaneous Integrated BoostIMRT; VMAT: Volumetric Modulated Arc Therapy; DA: Double Arc; SA: Single Arc; HT: Helical Tomotherapy; IFP: Improv...

Purpose To develop an artificial intelligence (AI) agent for fully automated rapid head-and-neck intensity-modulated radiation therapy (IMRT) plan generation without time-consuming dose-volume-based inverse planning. Methods This AI was trained via implementing a conditional generative adversarial network (cGAN) architecture. The generator, PyraNet, is novel deep learning that implements 28 cla...

We consider the problem of intensity-modulated radiation therapy (IMRT) treatment planning using direct aperture optimization. While this problem has been relatively well studied in recent years, most approaches employ a heuristic approach to the generation of apertures. In contrast, we use an exact approach that explicitly formulates the fluence map optimization (FMO) problem as a convex optim...

PURPOSE To investigate the role of beam orientation optimization in intensity-modulated radiation therapy (IMRT) and to examine the potential benefits of noncoplanar intensity-modulated beams. METHODS AND MATERIALS A beam orientation optimization algorithm was implemented. For this purpose, system variables were divided into two groups: beam position (gantry and table angles) and beam profile...

PURPOSE To develop a collimator trajectory optimization paradigm for volumetric modulated arc therapy (VMAT) and evaluate this technique in paraspinal stereotactic body radiation therapy (SBRT). METHOD AND MATERIALS We propose a novel VMAT paradigm, Coll-VMAT, which integrates collimator rotation with synchronized gantry rotation, multileaf collimator (MLC) motion, and dose-rate modulation. A...

PURPOSE To investigate the planning and dosimetric advantages of direct aperture optimization (DAO) over beam-let optimization in IMRT treatment of head and neck (H/N) and prostate cancers. METHODS Five Head and Neck as well as five prostate patients were planned using the beamlet optimizer in Elekta-Xio ver 4.6 IMRT treatment planning system. Based on our experience in beamlet IMRT optimizat...

background: external beam radiotherapy (ebrt) is mainstay of treatment in patients with locally advanced cervical carcinoma (lacc). three dimensional conformal radiotherapy (3dcrt) and intensity modulated radiotherapy (imrt) are mainly used in ebrt. however which one is superior is still controversial. materials and methods: forty patients of lacc treated with imrt were selected for this study....

PURPOSE A software program (MU-EPID) has been developed to perform patient specific IMRT pre-treatment QA verification using an electronic portal imaging device. METHODS The software converts measured images of intensity modulated beams delivered to an EPID, into fluence maps that can be imported in the treatment planning system. The dose can then be calculated in the patient anatomy and comp...