We have previously shown that the pulmonary venoconstriction produced by a stable thromboxane A2 analogue (STAJ is attenuated by prostacyclin (PGIi), but PGI, increases the STA2-induced edema. The present study was designed to determine the effects of STA2 and PGI2 on the fluid balance in isolated blood-perfused newborn lamb lungs. Vascular permeability was evaluated by use of the fluid filtrat...

Introduction and objective: In 1886, Starling proposed a hypothesis for the capillary–interstitial fluid (ISF) transfer, in which the capillary was thought a tube of a uniform diameter that is impermeable to plasma proteins. The flow of fluid across its wall was thought dependent upon a balance between the hydrostatic pressure within its lumen causing ‘filtration’, and the osmotic pressure of p...

Oedema and expansion of the extracellular fluid are well recognized as a complication of malnutrition in adults (McCance, 1951) as well as in children (Waterlow, Cravioto, and Stephen, 1960). An increase in total body water has also been described (Srikantia and Gopalan, 1957; Schnieden, Hendrickse, and Haigh, 1958; Smith, 1960). In the course of investigations on the renal function of malnouri...

We read with interest the article published by Bird et al about the reproducibility of measured GFR by iohexol and Cr-51-EDTA [ 1 ]. We would like to make one comment and to share our own results on this fundamental (although understudied) topic. As we already pointed out in a NDT editorial, we share the same reserves about the opportunity to index glomerular filtration rate (GFR) with body sur...

Water and electrolyte excretion has been studied in a series of dogs with diabetes insipidus, in which the extent of neurological damage was subsequently determined. The animals were studied before and after the introduction of variables which produce marked changes in the state of hydration,-administration and restriction of water and the substitution of 0.5 per cent sodium chloride for it as ...

The feasibility, validity, and possible applications of the assessment of extracellular fluid volume (ECFV) simultaneous with glomerular filtration rate (GFR) were assessed in a series of validation studies using the constant infusion method of (125)I-iothalamate (IOT). In 48 subjects with a broad range of GFR, distribution volume (V(d)) of IOT corresponded well with V(d) bromide (16.71 +/- 3.0...

Filtration products utilizing Nylon 6,6 membrane technology have demonstrated effectiveness in reducing microbridge defects in DUV photoresist patterning. The effects of fluid flow characteristics on defect reduction using a point-of-use Nylon 6,6 filtration product are explored. Lower filtration pressure and longer contact time were found to enhance the removal of gel-like microbridge defect p...

To compare effects of vibratory and mechanical ventilation on fluid balance in the newborn lung, we measured pulmonary arterial and left atrial pressures, pleural and airway pressures, lung blood flow and lymph flow, and concentrations of protein in lymph and plasma of 19 healthy lambs, 2-4 weeks old, during a 2- to 4-hour period of spontaneous breathing, followed by 4-8 hours of mechanical ven...

Integrated Ocean Drilling Program borehole CORK (Circulation Obviation Retrofit Kit) observatories provide long-term access to hydrothermal fluids circulating within the basaltic crust (basement), providing invaluable opportunities to study the deep biosphere. We describe the design and application parameters of the GeoMICROBE instrumented sled, an autonomous sensor and fluid sampling system. T...