نتایج جستجو برای: forced swim test

تعداد نتایج: 855638  

2016
Luis da Silva Abraão Tiago Batista Guimarães Raíssa de Oliveira Ferreira Wellington Alves Mizael da Silva André Luis da Silva Castro Guilherme Malafaia

Few studies have assessed the effects of tannery effluents intake in mammalian animal models, despite the discharge of tannery effluents into water bodies without treatment are environmental and public health problems in many countries. This study therefore aimed to evaluate the effects of the mice parental generation exposure to tannery effluent on the anxiety and depression behaviors in its o...

Journal: :Journal of psychopharmacology 2011
David A Slattery Inga D Neumann John F Cryan

Affective disorders are among the main causes of disability worldwide, yet the underlying pathophysiology remains poorly understood. Recently, landmark neuroimaging studies have shown increased metabolic activity in Brodmann Area 25 (BA25) in depressed patients. Moreover, functional inactivation of this region using deep brain stimulation alleviated depressive symptoms in severely depressed pat...

2017
Tomás E. Ceremuga

AANA Journal  August 2017  Vol. 85, No. 4 277 Anxiety and depression are debilitating, costly psychological disorders that account for $133 billion in direct medical expenses per year in the United States. Finding alternative means of treatment to reduce the personal and financial burden for patients with these disorders, while maintaining patient safety, is vital for overall patient wellness...

Journal: :Neuropharmacology 2004
Nicolas Singewald Catrin Sinner Alfred Hetzenauer Simone B Sartori Harald Murck

A relation between magnesium (Mg) status and mood disorders has been suggested, but evidence remains inconsistent. Therefore, we examined in mice whether Mg-depletion would alter behavior evaluated in established animal models of depression and anxiety and whether these effects would be sensitive to antidepressants. Compared to control mice fed with normal diet, mice receiving a low Mg diet (10...

Journal: :European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2005
Matthew N Hill Boris B Gorzalka

These experiments aimed to assess whether enhanced activity at the cannabinoid CB1 receptor elicits antidepressant-like effects. To examine this we administered 1 and 5 mg/kg doses of the endocannabinoid uptake inhibitor AM404; 5 and 25 microg/kg doses of HU-210, a potent CB1 receptor agonist; 1, 2.5 and 5 mg/kg of oleamide, which elicits cannabinoidergic actions; 1 and 5 mg/kg doses of AM 251,...

Journal: :Behavioural brain research 1998
G Liebsch A Montkowski F Holsboer R Landgraf

Over the past years, two breeding lines, derived originally from outbred Wistar rats, have been established that differ markedly and consistently in their anxiety-related behaviour in the elevated plus-maze. At the age of ten weeks, rats were tested once on the elevated plus-maze and the males and females displaying the most anxious and the least anxious behaviour were sib-mated to start a new ...

Journal: :Pharmacological reports : PR 2014
Sylwia Wośko Anna Serefko Katarzyna Socała Bernadeta Szewczyk Andrzej Wróbel Gabriel Nowak Piotr Wlaź Ewa Poleszak

BACKGROUND Spermine is one of the naturally occurring ligands that influence the function of the N-methyl-D-aspartate receptor. Similar to other endogenous polyamines present in micromolar concentration in the brain, it may play a role in the modulation of depression. Thus, the present study investigated the suggested antidepressant effect of spermine. METHODS The mouse forced swim test (FST)...

Journal: :The international journal of neuropsychopharmacology 2004
Todd D Gould Haim Einat Ratan Bhat Husseini K Manji

The mechanism by which lithium exerts either its anti-manic or antidepressant effects remains to be fully elucidated. Although lithium inhibits the enzyme glycogen synthase kinase-3 (GSK-3) at concentrations that are relevant for treatment of bipolar disorder, it is unclear whether GSK-3-related mechanisms are responsible for its therapeutic effects in the treatment of this disease. We report t...

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